Antidepressant Treatment of Very Old Patients

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Carl SalzmanB D Lebowitz

Abstract

Most studies of the elderly use age 65 as the definition of the onset of old age, and most studies of the pharmacologic treatment of depression in the elderly focus on patients between the ages of 60 and 70. Very few patients over the age of 75 have been specifically studied, and virtually none over the age of 80. Data for this review of treatment of depressed patients over the age of 75 were derived from a larger review prepared for a 1992 NIMH consensus development conference on the diagnosis and treatment of depression in late life. Available studies were divided into three categories: 1) mixed-age studies that include subjects over 75 (n = 18); 2) mixed-age reports of patients having a mean age of 75 or older (n = 13); and 3) reports including only patients with minimum age of 75 years or older (>n = 5). Data are available from only 171 identifiable patients over the age of 75. Consequently, available data for patients in this very old age category are too limited for reliable or valid treatment recommendations to be made; further research is necessary.

Citations

Dec 19, 1994·The American Journal of Medicine·C F Reynolds
Apr 1, 1995·Journal of Clinical Psychopharmacology·J C NelsonP I Jatlow
Jun 10, 2000·British Journal of Clinical Pharmacology·C Parikh
Aug 7, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·N A SinghM A Singh
Jun 29, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nalin A SinghMaria A Fiatarone Singh
Sep 1, 1995·Journal of Clinical Pharmacology·R A SweetC L DeVane

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