Antidepressant use and orthostatic hypotension in older adults living with mild-to-moderate Alzheimer disease.

International Journal of Geriatric Psychiatry
Adam H DyerNILVAD Study Group

Abstract

Antidepressant use is often reported as a risk factor for Orthostatic Hypotension (OH), however this relationship has never been explored in those with mild/moderate Alzheimer Disease (AD), who may represent a particularly vulnerable cohort. We performed a cross-sectional analysis of baseline data from the NILVAD study. Participants with mild-moderate AD were recruited from 23 centres in nine countries. Systolic and Diastolic Blood Pressure (SBP/DBP) was recorded in the seated position and after both 1 and 5 minutes of standing. OH was defined as a drop of ≥20 mmHg SBP/≥10 mmHg DBP. We examined the relationship between antidepressant use, orthostatic BP drop and the presence of OH, controlling for important covariates. Of 509 participants (72.9 ± 8.3 years, 61.9% female), two-fifths (39.1%; 199/509) were prescribed a regular antidepressant. Antidepressant use was associated with a significantly greater SBP and DBP drop at 5 minutes (β: 1.83, 0.16-3.50, P = .03 for SBP; β: 1.13, 0.02-2.25, P < .05 for DBP). Selective Serotonin Reuptake Inhibitor (SSRI) use was associated with a significantly greater likelihood of OH (OR 2.0, 1.1-3.6, P = .02). Both findings persisted following robust covariate adjustment. In older adults with AD...Continue Reading

References

Mar 1, 1997·Journal of Clinical Epidemiology·P CherinD Sereni
Aug 1, 1997·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·I Verhaeverbeke, T Mets
Oct 2, 2007·The American Journal of Medicine·Vishal Gupta, Lewis A Lipsitz
Jul 16, 2008·Journal of Clinical Psychopharmacology·Gijsbertus ZiereBruno H Ch Stricker
Sep 22, 2010·Journal of the Neurological Sciences·Shima MehrabianOlivier Hanon
Jan 17, 2012·The Journal of Clinical Psychiatry·Enrico TedeschiniGeorge I Papakostas
Feb 3, 2016·Therapeutic Advances in Drug Safety·Amanda Hanora Lavan, Paul Gallagher
Mar 16, 2017·Journal of the American Geriatrics Society·Ciarán FinucaneRose Anne Kenny
Jun 26, 2018·Journal of the American Society of Hypertension : JASH·R BriggsR A Kenny
Sep 25, 2018·PLoS Medicine·Brian LawlorUNKNOWN NILVAD Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Postgraduate Medical Journal
Jochanan E Naschitz, Itzhak Rosner
Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
M Bengtsson-LindbergE Londos
Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
Brett H Shaw, Victoria E Claydon
© 2021 Meta ULC. All rights reserved