Antidepressant use during pregnancy and asthma in the offspring

Pediatrics
Xiaoqin LiuJiong Li

Abstract

It has been suggested that maternal depression during pregnancy is associated with asthma in the offspring, but the role of medical treatment of depression is not known. Our goal was to examine whether prenatal antidepressant use increases the risk of asthma in the offspring. A cohort study was performed among all live singletons born in Denmark between 1996 and 2007. Mothers who had a diagnosis of depressive disorder and/or who used antidepressants 1 year before or during the index pregnancy were identified. Using a Cox proportional hazards regression model, we estimated the hazard ratio (HR) for asthma in the offspring after antidepressant use during pregnancy. Of the 733,685 children identified, 84,683 had a diagnosis of asthma. A total of 21,371 children were exposed to prenatal maternal depression (ie, a diagnosis of depressive disorder or use of antidepressants 1 year before or during pregnancy). Prenatal maternal depression was associated with childhood asthma (HR: 1.25 [95% confidence interval (CI): 1.20-1.30]). Overall, 8895 children were exposed to antidepressants in utero. Compared with children born to mothers with prenatal depression and no antidepressant use during pregnancy, the HR for asthma after any antidepres...Continue Reading

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Citations

Apr 23, 2016·Pediatric Pulmonology·David J BirnkrantTerry L Noah
Dec 16, 2017·American Journal of Epidemiology·Maria C MagnusWenche Nystad
Jan 14, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C FlaniganB I Nwaru
Oct 25, 2017·American Journal of Respiratory and Critical Care Medicine·Franca Rusconi, Luigi Gagliardi
Aug 1, 2020·Brain, Behavior, and Immunity·Xiaoqin LiuEsben Agerbo
Nov 10, 2021·Archives of public health = Archives belges de santé publique·Kabir AhmadRasheda Khanam

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