Antidepressants alter cerebrovascular permeability and metabolic rate in primates

S H PreskornB K Hartman


External detection of the annihilation radiation produced by water labeled with oxygen-15 was used to measure cerebrovascular permeability and cerebral blood flow in six rhesus monkeys. Use of oxygen-15 also permitted assessment of cerebral metabolic rate in two of the monkeys. Amitriptyline produced a dose-dependent, reversible increase in permeability at plasma drug concentrations which are therapeutic for depressed patients. At the same concentrations the drug also produced a 20 to 30 percent reduction in cerebral metabolic rate. At higher doses normal autoregulation of cerebral blood flow was suspended, but responsivity to arterial carbon dioxide was normal.


Jan 1, 1984·Psychopharmacology·S H PreskornJ V Solnick
Jan 30, 2002·Current Psychiatry Reports·M S NoblerH A Sackeim
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·G C Palmer
Jul 1, 1997·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·J E OlsonJ Evers
Nov 9, 2000·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·M S NoblerH A Sackeim
Mar 1, 1989·Biological Psychiatry·S H PreskornM Croskell
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M S BerridgeF Miraldi
Dec 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A H LockwoodF Napoleon
Dec 11, 1999·Journal of Geriatric Psychiatry and Neurology·M S NoblerH A Sackeim
Jul 31, 2004·Acta Psychiatrica Scandinavica·V A HolthoffK Herholz

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