Antidepressants and the Risk of Cardiovascular Events in Elderly Affected by Cardiovascular Disease: A Real-Life Investigation From Italy.

Journal of Clinical Psychopharmacology
Annalisa BiffiItalian Group for Appropriate Drug prescription in the Elderly (I-GrADE)

Abstract

The purpose of this study was to assess the possible relation between use of antidepressant (AD) drugs, that is, tricyclic ADs, selective serotonin reuptake inhibitors (SSRIs), and atypical ADs (AAs), and the risk of hospitalization for cardiovascular (CV) events among older patients with previous CV diseases. A nested case-control study was carried out among patients aged 65 years and older from 5 Italian health care territorial units who were discharged for CV disease during 2008 to 2010. The cohort was composed by 344,747 individuals, and of these, 97,739 (28%) experienced hospital admission for CV events (myocardial infarction, arrhythmia, stroke, heart failure) during follow-up (until 2014) and were included as cases. Up to 5 controls were randomly selected and matched to each. A conditional logistic regression was fitted to estimate the risk of CV events associated with ADs past or current use. A within-patient comparison was performed by the case-crossover design to account the effect of depression. Current users of SSRIs and AAs were at increased risk of CV events with odds ratios of 1.25 (95% confidence interval, 1.21-1.29) and 1.31 (1.25-1.37), respectively. An increased risk of arrhythmia and stroke was associated wi...Continue Reading

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Citations

Mar 23, 2020·Archives of Gynecology and Obstetrics·R T Amiel CastroP La Marca-Ghaemmaghami
May 28, 2021·Stroke; a Journal of Cerebral Circulation·Mu-Hong ChenYa-Mei Bai
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Oct 12, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Begüm Irmak ÖnLuisa Ibáñez

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