Antidepressants and their effect on cognition in major depressive disorder

The Journal of Clinical Psychiatry
George I Papakostas

Abstract

Cognitive functioning is a symptom of major depressive disorder (MDD) that deserves particular attention by clinicians and researchers. Despite the fact that cognitive dysfunction represents a symptom of MDD as well as a functional outcome measure, cognition has been insufficiently investigated in antidepressant trials. While, until recently, few placebo-controlled trials have measured cognition in MDD, those examples which did have consisted of older adults. Of agents tested thus far in placebo-controlled trials (citalopram, duloxetine, vortioxetine), only the latter has been studied in patients aged 18-65, and only the latter has been shown to be superior to placebo in improving measures of executive functioning and to do so across adult age groups. Both duloxetine and vortioxetine appear to result in greater improvements than placebo in immediate and delayed memory. Clinicians who wish to improve the psychosocial recovery of patients with MDD should be familiar with studies of new options for treatment.

Citations

Sep 24, 2016·Journal of Alzheimer's Disease : JAD·Cynthia L BetheaFernanda Lima Christian
Oct 1, 2019·Chinese Medical Journal·Qin-Bo HuQi Ma
May 21, 2020·The Journal of Nervous and Mental Disease·Bao-Hua ZhangGang Wang
Aug 15, 2018·Journal of Alzheimer's Disease : JAD·Elizabeth Guerrero-BerroaMichal Schnaider Beeri
Mar 4, 2021·Translational Psychiatry·M LyM A Butters

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