Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women

Journal of the American Heart Association
Lianne ParkinMillion Women Study Collaborators

Abstract

Some investigators have reported an excess risk of venous thromboembolism (VTE) associated with depression and with use of antidepressant drugs. We explored these associations in a large prospective study of UK women. The Million Women Study recruited 1.3 million women through the National Health Service Breast Screening Programme in England and Scotland. Three years after recruitment, women were sent a second questionnaire that enquired about depression and regular use of medications in the previous 4 weeks. The present analysis included those who responded and did not have prior VTE, cancer, or recent surgery. Follow-up for VTE was through linkage to routinely collected National Health Service statistics. Cox regression analyses yielded adjusted hazard ratios and 95% CIs. A total of 734 092 women (mean age 59.9 years) were included in the analysis; 6.9% reported use of antidepressants, 2.7% reported use of other psychotropic drugs, and 1.8% reported being treated for depression or anxiety but not use of psychotropic drugs. During follow-up for an average of 7.3 years,3922 women were hospitalized for and/or died from VTE. Women who reported antidepressant use had a significantly higher risk of VTE than women who reported neith...Continue Reading

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Citations

Jun 5, 2018·Platelets·Elmina Mammadova-BachDaniel Duerschmied
Sep 11, 2018·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·David GrahamMark Walker
May 19, 2017·Journal of the American Heart Association·Brian R Branchford
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Feb 6, 2019·European Journal of Clinical Pharmacology·Alenka Premuš Marušič KovačičDanijel Petrovič
Dec 28, 2018·Psychiatry and Clinical Neurosciences·Takuto IshidaHiroyuki Uchida
Feb 13, 2020·Hospital Pediatrics·Catherine E RossMichael W Donnino
Mar 13, 2020·Neuropsychiatric Disease and Treatment·Masahiro TakeshimaKazuo Mishima
Apr 27, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Rakel M ZarbKarri A Adamson
Nov 7, 2020·Journal of Thrombosis and Thrombolysis·Marina RiederDaniel Duerschmied

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