PMID: 12785461Jun 6, 2003Paper

Antidepressants for the treatment of depression in people with schizophrenia: a systematic review

Psychological Medicine
C WhiteheadG Lewis

Abstract

Depression is common in people with schizophrenia and is associated with substantial morbidity and an increased risk of suicide. Our aim was to review systematically all the randomized controlled trials that have investigated the clinical effectiveness of antidepressant medication in the treatment of depression in people who also suffer with schizophrenia. Electronic searches of ClinPsych, the Cochrane Library, the Cochrane Schizophrenia Group's Register of Trials, EMBASE and Medline were completed. Reference lists from identified articles were hand searched. Eleven small studies were identified and all randomized fewer than 30 subjects to each group. We could only perform analyses on a subset of the trials. For five trials (aggregate N = 209) the proportion improved in the antidepressant group was 26% (95% CI 10% to 42%) higher than in the placebo group. In six studies (aggregate N = 267) the standardized mean difference on the Hamilton Rating Scale for Depression at the end of the trial was -0.27 (95 % CI -0.7 to 0.2). There was no evidence that antidepressant treatment given during the stable phase of illness led to a deterioration of psychotic symptoms in the included trials. The literature reviewed was, overall, of poor qu...Continue Reading

Associated Clinical Trials

Citations

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Jul 5, 2005·European Archives of Psychiatry and Clinical Neuroscience·Max BirchwoodRachel Upthegrove
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Jan 21, 2011·Current Opinion in Psychiatry·Peter F BuckleyKristy R Howell
Mar 21, 2007·Annals of General Psychiatry·Maurizio PompiliRoberto Tatarelli
May 26, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Janusz K RybakowskiUNKNOWN EUFEST Study Group
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