Antidepressants for treating depression in dementia

The Cochrane Database of Systematic Reviews
Robert DudasTom Dening

Abstract

The use of antidepressants in dementia accompanied by depressive symptoms is widespread, but their clinical efficacy is uncertain. This review updates an earlier version, first published in 2002. To determine the efficacy and safety of any type of antidepressant for patients who have been diagnosed as having dementia of any type and depression as defined by recognised criteria. We searched ALOIS, the Cochrane Dementia and Cognitive Improvement Group's Specialised Register, on 16 August 2017. ALOIS contains information on trials retrieved from databases and from a number of trial registers and grey literature sources. We included all relevant double-blind, randomised trials comparing any antidepressant drug with placebo, for patients diagnosed as having dementia and depression. Two review authors selected studies for inclusion and extracted data independently. We assessed risk of bias in the included studies using the Cochrane 'Risk of bias' tool. Where clinically appropriate, we pooled data for treatment periods up to three months and from three to nine months. We used GRADE methods to assess the overall quality of the evidence. We included ten studies with a total of 1592 patients. Eight included studies reported sufficiently ...Continue Reading

References

Aug 1, 1978·Journal of the American Geriatrics Society·B Capote, N Parikh
Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1992·International Clinical Psychopharmacology·C G GottfriesA L Nyth
Dec 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·A L Nyth, C G Gottfries
Jan 1, 1991·Annals of the New York Academy of Sciences·C G Gottfries, A L Nyth
Aug 1, 1990·Psychological Medicine·M A AbasR Levy
Jan 1, 1989·The American Journal of Psychiatry·B V ReiflerP McLean
Feb 1, 1988·Biological Psychiatry·G S AlexopoulosC A Shamoian
Dec 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·I M Wilkinson, J Graham-White
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Jul 1, 1981·Archives of General Psychiatry·A H Glassman, J T Bigger
Oct 1, 1994·Journal of Geriatric Psychiatry and Neurology·S VidaS Gauthier
Feb 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·M RothR Amrein
May 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·Y BarakR H Belmaker
Jan 1, 1996·The Journal of Neuropsychiatry and Clinical Neurosciences·G PetraccaS E Starkstein
Apr 30, 1999·BMJ : British Medical Journal·D G Altman, J M Bland
Jan 29, 2000·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·C MagaiD Gomberg
Apr 29, 2000·Annals of Internal Medicine·J W WilliamsJ Cornell
May 10, 2000·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·D W OslinT Cooper
May 10, 2000·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·J E StreimT Ten Have
Jul 27, 2000·The American Journal of Psychiatry·G Parker
Aug 10, 2001·International Psychogeriatrics·G M PetraccaS E Starkstein
Feb 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Alistair BurnsSarah Craig
Apr 2, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jason T OlinBarry D Lebowitz
Jan 10, 2003·The Cochrane Database of Systematic Reviews·Jatinder BainsTom Dening
Feb 7, 2003·International Journal of Geriatric Psychiatry·D P DevanandHarold A Sackeim
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Feb 6, 2004·International Journal of Geriatric Psychiatry·Martin SteinbergConstantine G Lyketsos
Jun 21, 2006·Expert Review of Neurotherapeutics·Sergio E Starkstein, Romina Mizrahi
Sep 7, 2006·International Journal of Geriatric Psychiatry·J Craig NelsonUNKNOWN Mirtazapine Nursing Home Study Group

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Citations

Aug 23, 2019·Neurology and Therapy·Anna D BurkeSehar Khokher
Jul 7, 2019·Current Psychiatry Reports·Kathleen S BinghamBenoit H Mulsant
Sep 29, 2019·Evidence-based Mental Health·Nina BaruchCharlotte Louise Allan
Aug 28, 2020·Frontiers in Pharmacology·Radoslaw MagierskiDorota Religa
May 11, 2021·Frontiers in Psychiatry·Ruben MuñizJavier Olazarán
Aug 8, 2021·International Journal of Environmental Research and Public Health·Sun-Hong BaekSang-Kab Park
Nov 27, 2021·Zeitschrift für Gerontologie und Geriatrie·Vjera Holthoff-Detto, Kathrin Seifert

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