Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review

Acta Dermato-venereologica
Shirin EskelandLars Tanum

Abstract

There is increasing evidence of clinically relevant anti-inflammatory effects of monoaminergic antidepressants. PubMed and Ovid databases were searched systematically for the use and efficacy of antidepressants in association with 5 common inflammatory skin disorders: chronic urticaria, psoriasis, atopic dermatitis, other eczema, and alopecia areata. From January 1984 to June 2016, publications included a total of 1,252 dermatological patients in 28 trials or case reports. These unambiguously reported a reduced burden of dermatological symptoms in relation to treatment with antidepressants. Several randomized controlled trials of first-generation antidepressants have been published, while studies of modern antidepressants are usually open-label, yet more informative, regarding patients' characteristics and study procedures. These overall positive findings may indicate a rationale, beyond treating comorbid psychiatric disorders, for the use of antidepressants in dermatology. Further research into modern tolerable antidepressants, including selective serotonin re-uptake inhibitors, mirtazapine and bupropion, is required.

Citations

Sep 15, 2020·Dermatologic Therapy·Israel González-UrbietaJulio Torales
Sep 30, 2020·Expert Opinion on Pharmacotherapy·Kam Lun HonVivian W Y Lee
Feb 18, 2020·Molecular Neurobiology·Ana M MartinsJoana Marto
Mar 3, 2020·Frontiers in Immunology·Minjie WanPujun Gao
Nov 23, 2020·Archives of Dermatological Research·Marissa T AyasseJonathan I Silverberg
Nov 19, 2020·Dermatology and Therapy·Guang ChenJin-Guang Chen
Sep 4, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Yochai SchonmannSinéad M Langan
Nov 3, 2021·Experimental Dermatology·Claudia Cervantes-DuránMartha-Estrella García-Pérez

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