Antidepressants have complex associations with longitudinal depressive burden in bipolar disorder

Journal of Affective Disorders
Farnaz HooshmandTerence A Ketter

Abstract

Antidepressants are common in bipolar disorder (BD), but controversial due to questionable efficacy/tolerability. We assessed baseline antidepressant use/depression associations in BD. Stanford BD Clinic outpatients, enrolled during 2000-2011, assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation, were monitored up to two years with the STEP-BD Clinical Monitoring Form while receiving naturalistic expert treatment. Prevalence/correlates of baseline antidepressant use in recovered (euthymic ≥8 weeks)/depressed patients were assessed. Kaplan-Meier survival analyses assessed times to depressive recurrence/recovery in patients with/without baseline antidepressant use, and Cox Proportional Hazard regression analyses assessed covariate effects. Baseline antidepressant use was significantly (albeit without Bonferroni multiple comparison correction) less among 105 recovered (31.4%) versus 153 depressed (44.4%) patients, and among recovered patients (again without Bonferroni correction), associated with Caucasian race, earlier onset, worse Clinical Global Impression scores, and hastened depressive recurrence (only if mood elevation episodes were not censored), driven by lifetime anxie...Continue Reading

References

Dec 1, 1990·Archives of General Psychiatry·M TohenM T Tsuang
Dec 14, 2002·Bipolar Disorders·Gary S SachsStephanie L McMurrich
Nov 12, 2003·Archives of General Psychiatry·Mauricio TohenAlan Breier
Mar 31, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Eduard Vieta
Jul 4, 2006·The British Journal of Psychiatry : the Journal of Mental Science·M W OttoUNKNOWN STEP-BD Investigators
Jan 12, 2007·Psychiatric Services : a Journal of the American Psychiatric Association·Ross J BaldessariniJohn Hennen
Mar 30, 2007·The New England Journal of Medicine·Gary S SachsMichael E Thase
Aug 30, 2008·Acta Psychiatrica Scandinavica·S N GhaemiR J Baldessarini
Nov 19, 2008·The American Journal of Psychiatry·Mark A FryeTrisha Suppes
Feb 4, 2010·The Journal of Clinical Psychiatry·Susan L McElroyUNKNOWN EMBOLDEN II (Trial D1447C00134) Investigators
Nov 3, 2010·The Journal of Clinical Psychiatry·Michelle M Sidor, Glenda M Macqueen
Apr 18, 2012·The Australian and New Zealand Journal of Psychiatry·Joseph F Goldberg
Apr 25, 2012·Bipolar Disorders·Michael BauerAndrea Pfennig
Feb 23, 2013·The International Journal of Neuropsychopharmacology·Gustavo H VázquezRoss J Baldessarini
Sep 14, 2013·The American Journal of Psychiatry·Isabella PacchiarottiEduard Vieta
Aug 5, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Gustavo H VázquezRoss J Baldessarini

❮ Previous
Next ❯

Citations

Nov 11, 2020·ELife·Paolo OssolaCarlo Marchesi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.