Antidepressants Impact Connexin 43 Channel Functions in Astrocytes

Frontiers in Cellular Neuroscience
Tiffany JeansonChristian Giaume

Abstract

Glial cells, and in particular astrocytes, are crucial to maintain neuronal microenvironment by regulating energy metabolism, neurotransmitter uptake, gliotransmission, and synaptic development. Moreover, a typical feature of astrocytes is their high expression level of connexins, a family of membrane proteins that form gap junction channels allowing intercellular exchanges and hemichannels that provide release and uptake pathways for neuroactive molecules. Interestingly, several studies have revealed unexpected changes in astrocytes from depressive patients and rodent models of depressive-like behavior. Moreover, changes in the expression level of the astroglial connexin 43 (Cx43) have been reported in a depressive context. On the other hand, antidepressive drugs have also been shown to impact the expression of this connexin in astrocytes. However, so far there is little information concerning the functional consequence of these changes, i.e., the status of gap junctional communication and hemichannel activity in astrocytes exposed to antidepressants. In the present work we focused our attention on the action of seven antidepressants from four different therapeutic classes and tested their effects on Cx43 expression and on the...Continue Reading

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Citations

Aug 5, 2016·Frontiers in Integrative Neuroscience·Juan A OrellanaJimmy Stehberg
Dec 5, 2017·Frontiers in Molecular Neuroscience·Mauricio A RetamalJulio Alcayaga
Oct 27, 2017·Frontiers in Molecular Neuroscience·Denis SarrouilheMarc Mesnil
Mar 29, 2018·Current Medicinal Chemistry·Denis SarrouilheCatherine Dejean
Feb 23, 2020·Frontiers in Molecular Neuroscience·Peter IllesYong Tang
Jul 12, 2017·Frontiers in Cellular Neuroscience·Mathieu CharvériatChristian Giaume
Apr 25, 2020·Physiological Reviews·Christian GiaumeLuc Leybaert
Jan 6, 2021·International Journal of Molecular Sciences·Motohiro OkadaTakashi Shiroyama
Jun 3, 2021·International Journal of Molecular Sciences·Kouji Fukuyama, Motohiro Okada

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Methods Mentioned

BETA
FCS
scraping
protein assay

Software Mentioned

GraphPad Prism
NIS Nikon
ImageJ
Image J

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