PMID: 2110637Mar 26, 1990Paper

Antidepressants induce regeneration of catecholaminergic axon terminals in the rat cerebral cortex

Neuroscience Letters
S Nakamura

Abstract

Although repeated but not single administration of antidepressants exerts therapeutic effect on clinical depression, the mechanism of the clinical efficacy of antidepressants remains unknown. This report shows a novel action of antidepressants which can explain the delayed onset of clinical action of the drugs. Continuous infusion of the antidepressants maprotiline or desipramine into the rat cerebral cortex pretreated with the catecholamine neurotoxin 6-hydroxydopamine induced regeneration of noradrenergic axon terminals. This finding provides evidence that antidepressants possess the ability to cause axonal sprouting of central noradrenergic (and possibly dopaminergic) neurons in the mature brain.

References

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Citations

Dec 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·C M ContrerasG Arrellín-Rosas
Jan 1, 1994·Brain Research Bulletin·I KitayamaK Nakano
Aug 27, 1997·European Journal of Pharmacology·S MiyamotoA Aoba
Apr 2, 1999·Trends in Pharmacological Sciences·C A Altar
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ana G Gutiérrez-GarcíaMargarita Saavedra
Dec 11, 1999·Schizophrenia Research·P J Harrison
Mar 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·M M C Gonzalez, G Aston-Jones
Nov 26, 2003·Experimental Neurology·Ying LiuShoji Nakamura
Sep 9, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Junlin ZhangRick C S Lin
Nov 14, 2006·Biochemical Pharmacology·Eric A StoneMichael L Lehmann
Nov 23, 2005·Journal of Neurochemistry·Lijun ZhouVassilis E Koliatsos
Jan 6, 2009·Annals of the New York Academy of Sciences·Isao T KitayamaSumio Murase
Dec 29, 2000·Molecular Psychiatry·H K ManjiG Chen
Feb 13, 2002·Sports Medicine·Lawrence E Armstrong, Jaci L VanHeest
May 10, 1995·Annals of the New York Academy of Sciences·M M Mesulam
Feb 22, 2012·Journal of Cross-cultural Gerontology·Usha Menon
Feb 16, 2007·Neuroreport·Junko IshikawaShoji Nakamura
May 25, 2002·CNS Drugs·José Javier Miguel-Hidalgo, Grazyna Rajkowska
Nov 20, 1995·The Journal of Comparative Neurology·C M PadenM M Oblinger

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