Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type-2 diabetes

Phytotherapy Research : PTR
Sameer SharmaAbhijit Ray

Abstract

In the present study, resveratrol, a polyphenolic SIRT1 activator was evaluated for its SIRT1 activation in an in vitro fluorescent based assay (EC(50) : 7 μM). The efficacy of resveratrol was also evaluated in ob/ob mice for its antidiabetic and associated metabolic effects. Mice aged 5-8 weeks were included in four groups; control and resveratrol at 5, 15, 50 mg/kg, b.i.d. and were dosed orally. After 4 weeks of drug treatment, body weights were noted and random blood glucose and insulin was estimated for the antidiabetic effect. Animals were also subjected to the oral glucose tolerance test to observe any improvement in the glucose excursion. Triglycerides, total cholesterol, adiponectin and free fatty acid levels were also estimated. The results showed that resveratrol exhibited significant antihyperglycemic activity with an improvement in the insulin levels compared with the control mice. There was also a significant improvement observed in the glucose excursion in the oral glucose tolerance test performed for 120 min; although an insignificant improvement in the triglycerides, total cholesterol, adiponectin and free fatty acid levels was observed at different doses of resveratrol tested. The present findings suggest that ...Continue Reading

References

Jan 1, 1994·The Medical Clinics of North America·H N Ginsberg
Sep 22, 1999·European Journal of Biochemistry·M MacCarroneA F Agrò
Jul 16, 2002·The Journal of Biological Chemistry·Mary E Waltner-LawDaryl K Granner
Dec 28, 2002·Journal of Agricultural and Food Chemistry·Nicolas LandraultPierre-Louis Teissedre
Jun 4, 2004·Nature·Frédéric PicardLeonard Guarente
Nov 16, 2005·Pharmacology·Sameer SharmaKanwaljit Chopra
Jan 26, 2006·American Journal of Physiology. Endocrinology and Metabolism·Hui-Chen SuJan-Kan Chen
Apr 21, 2007·Circulation Research·Ralph R AlcendorJunichi Sadoshima
May 26, 2007·Circulation Research·Daniel Sedding, Judith Haendeler
Sep 19, 2007·The Journal of Pharmacology and Experimental Therapeutics·Brett BursteinStanley Nattel
Jun 10, 2008·Endocrine, Metabolic & Immune Disorders Drug Targets·Ling LiuAimin Xu
Jun 26, 2008·Biochemical and Biophysical Research Communications·Wei-jian Jiang
Jul 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Paul T PflugerMatthias H Tschöp
Aug 5, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P Palsamy, S Subramanian
Aug 30, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joanne M AjmoMin You
Oct 9, 2008·Cell Metabolism·Alexander S BanksDomenico Accili
Nov 11, 2008·Recent Patents on Cardiovascular Drug Discovery·Sivaram Pillarisetti
Oct 13, 2009·Endocrinology·Giorgio RamadoriRoberto Coppari

❮ Previous
Next ❯

Citations

Nov 1, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hong-Feng YuanXue-Tao Pei
Apr 2, 2011·Journal of Physiology and Biochemistry·Noemi AriasMaría Puy Portillo
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Albino CarrizzoCarmine Vecchione
Jan 6, 2011·Diabetes, Obesity & Metabolism·W Xie, L Du
Jan 22, 2011·Journal of Biomedicine & Biotechnology·Sunil K Panchal, Lindsay Brown
Jun 27, 2014·BioMed Research International·Stephanie A SegoviaClare M Reynolds
Sep 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ali MovahedThomas Netticadan
May 17, 2014·Expert Opinion on Drug Delivery·Rudra PangeniSanjula Baboota
Mar 19, 2014·Metabolism: Clinical and Experimental·Soo Jin Yang, Yunsook Lim
Feb 15, 2013·Pharmacological Reports : PR·Farhad Ghadiri SoufiHamid Ahmadieh
Feb 24, 2016·Journal of Immunology Research·Vidula T VachharajaniCharles E McCall
Dec 20, 2011·Preventive Medicine·Irfan RahmanHongwei Yao
Nov 6, 2014·Clinical and Experimental Pharmacology & Physiology·Farhad Ghadiri SoufiHamid Ahmadieh
May 17, 2011·Free Radical Biology & Medicine·Yi HuQingsong Liu
Nov 7, 2012·Journal of Ethnopharmacology·Prishania PillayJohannes Bodenstein
Aug 21, 2012·Nutrition Research·Jayesh Kumar BhattMoola Joghee Nanjan
Dec 4, 2014·Fertility and Sterility·Estefanía CabelloCelestino González
Oct 29, 2013·Oxidative Medicine and Cellular Longevity·Shraddha D RegeJeganathan Ramesh Babu
May 2, 2016·Environmental Toxicology and Pharmacology·Chang FengGuangqin Fan
Feb 26, 2013·Experimental Biology and Medicine·Chandra K SinghUgra S Singh
Oct 17, 2016·Biological Trace Element Research·Soheila AsadiMarzieh Mahmoodi
Jan 18, 2017·Medicinal Research Reviews·Matthias SchiedelManfred Jung
Nov 17, 2015·Nutrients·Charlotte GrootaertJohn Van Camp
Dec 20, 2017·Antioxidants & Redox Signaling·Susana Rovira-LlopisVictor M Victor
Mar 20, 2019·Diabetes/metabolism Research and Reviews·Gloria FormosoAgostino Consoli
Jan 7, 2019·European Journal of Medicinal Chemistry·Priscila Baltazar Gonçalves, Nelilma Correia Romeiro
Aug 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ebru ÖztürkAnupam Bishayee
Feb 15, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dan-Dan HuangChuanlin Zhu
Mar 5, 2021·Life Sciences·Arpita AroraSimona Bungau
May 30, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hamideh VahidAhmad Ghorbani
Nov 10, 2021·European Journal of Ophthalmology·Irini ChatziralliPanagiotis Theodossiadis

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