Abstract
Dioscoreophyllum cumminsii (Stapf) Diels leaves are used in the management of diabetics in Nigeria. Thus, the antidiabetic activity of aqueous D. cumminsii leaf extract and its capability to halt oxidative stress and dyslipidemia in alloxan-induced diabetic rats was investigated. Antidiabetic was evaluated in alloxan-induced diabetes rats. Diabetic rats were treated with 50, 100 and 200mg/kg body weight of the extract. The aqueous extract of D. cumminsii leaves significantly reduced blood glucose level in a dose dependent manner with highest dose producing 72% reduction after 21 days administration, which was compared significantly (P<0.05) with the control group and glibenclamide treated groups. Similarly, aqueous extract of D. cumminsii significantly reversed reduction in insulin in alloxan-induced diabetic rats. Alloxan-induced diabetic mediated alterations in liver and serum cholesterol, triacylglycerides, high-density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDLc) and very low-density lipoprotein cholesterol (VLDLc) were significantly (P<0.05) restored by the extract. Aqueous extract of D. cumminsii leaves significantly attenuated the decrease in the activities of superoxide dismutase, catalase,...Continue Reading
References
May 1, 1996·Kidney International·V Witko-SarsatB Descamps-Latscha
Dec 18, 2001·Chemical Research in Toxicology·T P ReillyL R Pohl
Feb 15, 2002·Diabetes, Obesity & Metabolism·Alan J Garber
Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Isabella Dalle-DonneRoberto Colombo
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Aug 2, 2005·Journal of Ethnopharmacology·S RoyV L Kumar
Nov 15, 2006·Journal of Ethnopharmacology·Aylin Sepici-DincelErdem Yeşilada
Sep 1, 2007·Journal of the Society for Integrative Oncology·Andrew J Vickers
Mar 26, 2008·Journal of Medicinal Food·Myoung-Nam WooMyung-Sook Choi
Jan 24, 2009·Journal of Ethnopharmacology·Yi-Jou HsuWen-Chin Yang
Jun 9, 2009·Free Radical Biology & Medicine·Etsuo Niki
Sep 5, 2009·Drug and Chemical Toxicology·Taofeek O AjiboyeJoseph I Okogun
Sep 17, 2009·Human & Experimental Toxicology·M T YakubuM A Akanji
May 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mediha SefiNajiba Zeghal
Aug 13, 2010·The Review of Diabetic Studies : RDS·Dario PitoccoGiovanni Ghirlanda
Aug 13, 2010·Endocrine·Nilgün AltanAtilla Engin
Oct 29, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·B Shivananda NayakAndrew Adogwa
Oct 29, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·Debasis DeDebidas Ghosh
Dec 18, 2010·Free Radical Biology & Medicine·Justin L Rains, Sushil K Jain
Mar 19, 2011·Journal of Ethnopharmacology·Mediha SefiNajiba Zeghal
Jun 15, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mayurkumar B Patel, Shrihari Mishra
Oct 5, 2011·Indian Journal of Pharmaceutical Sciences·V Sivakumar, M S Dhana Rajan
Oct 12, 2011·Circulation·Fiona C McGillicuddyDaniel J Rader
Aug 22, 2013·Journal of Biochemical and Molecular Toxicology·Taofeek O AjiboyeAdenike T Oladiji
Aug 31, 2014·Journal of Ethnopharmacology·O B OloyedeA O Adeleye
Citations
Feb 24, 2016·Journal of Ethnopharmacology·A O SulymanH F Muritala
Oct 4, 2015·Diabetes/metabolism Research and Reviews·Gislaine Z RéusJoão Quevedo
Dec 10, 2015·BioMed Research International·Abinaya ManivannanByoung Ryong Jeong
Aug 6, 2016·Inflammation·Sahabuddin AhmedMangala Lahkar
Aug 30, 2016·Journal of Ethnopharmacology·T O AjiboyeO B Ibitoye
Oct 19, 2016·Journal of Ethnopharmacology·Zhihui LiuJun Yin
Sep 23, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Ahmad Khusairi AzemiAida Hanum Ghulam Rasool
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·O B IbitoyeT O Ajiboye
Jul 30, 2019·Journal of Food Biochemistry·Emmanuel Ohifueme AlegbeTaofeek Olakunle Ajiboye
Jul 6, 2017·Chemistry & Biodiversity·Opeyemi J OlatunjiYifeng Zhou
Jan 6, 2021·IET Nanobiotechnology·Ragavee AmbalavananAsha Devi Selvaraj
Feb 27, 2020·Current Pharmaceutical Biotechnology·Jinfeng YangMyong Jo Kim
Jul 2, 2021·Journal of Traditional and Complementary Medicine·Babalola Ola YusufMusbau Adewumi Akanji
Sep 4, 2018·Journal of Ethnopharmacology·Humberto de Moura BarbosaEduardo Carvalho Lira
Jan 30, 2021·Protein and Peptide Letters·Victor Hugo Dantas GuimarãesSérgio Henrique Sousa Santos