Antidiabetic and antidyslipidemic activities of aqueous leaf extract of Dioscoreophyllum cumminsii (Stapf) Diels in alloxan-induced diabetic rats

Journal of Ethnopharmacology
H O B OloyedeM O Salawu

Abstract

Dioscoreophyllum cumminsii (Stapf) Diels leaves are used in the management of diabetics in Nigeria. Thus, the antidiabetic activity of aqueous D. cumminsii leaf extract and its capability to halt oxidative stress and dyslipidemia in alloxan-induced diabetic rats was investigated. Antidiabetic was evaluated in alloxan-induced diabetes rats. Diabetic rats were treated with 50, 100 and 200mg/kg body weight of the extract. The aqueous extract of D. cumminsii leaves significantly reduced blood glucose level in a dose dependent manner with highest dose producing 72% reduction after 21 days administration, which was compared significantly (P<0.05) with the control group and glibenclamide treated groups. Similarly, aqueous extract of D. cumminsii significantly reversed reduction in insulin in alloxan-induced diabetic rats. Alloxan-induced diabetic mediated alterations in liver and serum cholesterol, triacylglycerides, high-density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDLc) and very low-density lipoprotein cholesterol (VLDLc) were significantly (P<0.05) restored by the extract. Aqueous extract of D. cumminsii leaves significantly attenuated the decrease in the activities of superoxide dismutase, catalase,...Continue Reading

References

May 1, 1996·Kidney International·V Witko-SarsatB Descamps-Latscha
Dec 18, 2001·Chemical Research in Toxicology·T P ReillyL R Pohl
Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Isabella Dalle-DonneRoberto Colombo
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Nov 15, 2006·Journal of Ethnopharmacology·Aylin Sepici-DincelErdem Yeşilada
Sep 1, 2007·Journal of the Society for Integrative Oncology·Andrew J Vickers
Jan 24, 2009·Journal of Ethnopharmacology·Yi-Jou HsuWen-Chin Yang
Jun 9, 2009·Free Radical Biology & Medicine·Etsuo Niki
May 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mediha SefiNajiba Zeghal
Aug 13, 2010·The Review of Diabetic Studies : RDS·Dario PitoccoGiovanni Ghirlanda
Oct 29, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·B Shivananda NayakAndrew Adogwa
Dec 18, 2010·Free Radical Biology & Medicine·Justin L Rains, Sushil K Jain
Jun 15, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mayurkumar B Patel, Shrihari Mishra
Oct 5, 2011·Indian Journal of Pharmaceutical Sciences·V Sivakumar, M S Dhana Rajan
Aug 22, 2013·Journal of Biochemical and Molecular Toxicology·Taofeek O AjiboyeAdenike T Oladiji

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Citations

Feb 24, 2016·Journal of Ethnopharmacology·A O SulymanH F Muritala
Sep 23, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Ahmad Khusairi AzemiAida Hanum Ghulam Rasool
Jul 30, 2019·Journal of Food Biochemistry·Emmanuel Ohifueme AlegbeTaofeek Olakunle Ajiboye
Feb 27, 2020·Current Pharmaceutical Biotechnology·Jinfeng YangMyong Jo Kim
Jul 2, 2021·Journal of Traditional and Complementary Medicine·Babalola Ola YusufMusbau Adewumi Akanji
Sep 4, 2018·Journal of Ethnopharmacology·Humberto de Moura BarbosaEduardo Carvalho Lira
Jan 30, 2021·Protein and Peptide Letters·Victor Hugo Dantas GuimarãesSérgio Henrique Sousa Santos

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