Antidiabetic and antioxidant activities of Nypa fruticans Wurmb. vinegar sample from Malaysia

Asian Pacific Journal of Tropical Medicine
Nor Adlin YusoffMohd Z Asmawi

Abstract

To study the antidiabetic and antioxidant activities of nipa palm vinegar (NPV) used in traditional Malay medicine for treating diabetes. NPV was extracted using liquid-liquid extraction method and the obtained samples were subjected to antidiabetic studies using normal and streptozotocin-induced diabetic rat models whereas antidoxidant activities were investigated via in vitro antioxidant tests namely 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid free radicals scavenging activities and the reducing power assay. Single administration of NPV and its extracts were not effective in both normal and diabetic rats. In intraperitoneal glucose tolerance test, NPV and its aqueous extract showed significant blood glucose lowering effect. In the sub-acute study, compared with the diabetic control, aqueous extract of NPV showed the most notable blood glucose lowering effect (56.6%) and a significant improvement in serum insulin levels (79.8%, P < 0.05). To assess NPV's antioxidant activity, three in vitro antioxidant tests were employed: 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid free radical-scavenging assays, and the reducing power assay. Ethyl acetate e...Continue Reading

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Citations

Apr 21, 2019·Marine Drugs·Sadeer Nabeelah BibiShunmugiah Karutha Pandian
Oct 3, 2019·Biomolecules·Bahare SalehiJavad Sharifi-Rad
Sep 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Moragot Chatatikun, Wiyada Kwanhian
Jul 21, 2020·Oxidative Medicine and Cellular Longevity·Hee-Jeong ChoiSang-Han Lee
May 23, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Rita-Cindy Aye-Ayire SedjoahHui Yan
Aug 16, 2021·Drug Metabolism and Personalized Therapy·Abdulhakim AbubakarEzzeldin Mukthar Abdurahman

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