Antidiabetic effects of corosolic acid in KK-Ay diabetic mice

Biological & Pharmaceutical Bulletin
T MiuraY Seino

Abstract

The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. CA (2 mg/kg) reduced the blood glucose levels in KK-Ay mice 2 weeks after a single oral dose and also significantly lowered plasma insulin levels were in KK-Ay mice under similar conditions. CA-treated KK-Ay mouse blood glucose significantly decreased in an insulin tolerance test. These results support the hypothesis that CA improves glucose metabolism by reducing insulin resistance. Therefore CA may be useful for the treatment of type 2 diabetes.

References

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Citations

Jan 30, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Guy KleinXiaozhuo Chen
Jul 19, 2008·Journal of Nutritional Science and Vitaminology·Satoshi TakagiTorao Ishida
Oct 20, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Toshihiro MiuraTorao Ishida
Apr 2, 2008·Biological & Pharmaceutical Bulletin·Kotaro YamadaNobuya Inagaki
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Mar 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kyoung Jin NhoHo Kyoung Kim
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Apr 13, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Feng LiYanghao Guo
Nov 14, 2020·International Journal of Molecular Sciences·Ga-Eun LimYong-Nyun Kim
Aug 31, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xu-Ping QianYong-Qing Wang

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