PMID: 16502763Mar 1, 2006Paper

Antidiabetic medications in overdose: a comparison of the inquiries made to a regional poisons unit regarding original sulfonylureas, biguanides and insulin

International Journal of Clinical Pharmacology and Therapeutics
M A von MachL S Weilemann

Abstract

The drugs most commonly used to treat diabetes mellitus are sulfonylureas, biguanides and insulin. The most serious effects seen in overdose with these agents are hypoglycemia or lactic acidosis which may be fatal or cause cerebral defects. The present investigation analyzes inquiries made to a regional poisons unit involving overdoses with sulfonylureas, biguanides and insulin. A total of 218,070 made inquiries between 1995 and 2004 were evaluated. The inquiries were received by telephone and a standardized questionnaire was sent subsequently to the physicians calling for follow-up information. The cases were analyzed with regard to gender, age, etiology, symptoms and clinical outcome. 263 inquiries concerning sulfonylureas (48.3% female, 49.4% male, 2.3% sex unknown, average age 39.1 +/- 26.8 years), 172 concerning biguanides (60.5% female, 37.2% male, 2.3% sex unknown, average age 41.5 +/- 24.1 years), and 191 concerning insulin (53.9% female, 41.9% male, 4.2% sex unknown, average age 44.6 +/- 16.7) were made. In cases involving sulfonylureas, the etiology was deliberate self-poisoning in 62.7% and accidental in 31.9% (biguanides 60.5% and 29.1%, insulin 85.3% and 9.4%). Using the Poisoning Severity Score, no symptoms were o...Continue Reading

Citations

Aug 2, 2012·Journal of Bioinformatics and Computational Biology·Alok SharmaSatoru Miyano
Oct 30, 2007·Critical Care : the Official Journal of the Critical Care Forum·Bruno MégarbaneFrédéric J Baud
Dec 4, 2009·Primary Care Companion to the Journal of Clinical Psychiatry·Kristin S RussellTheodore A Stern
Dec 20, 2012·Wiener klinische Wochenschrift·Heidemarie AbrahamianHermann Toplak
Jan 10, 2018·Basic & Clinical Pharmacology & Toxicology·Nicklas Järvelä Johansen, Mikkel Bring Christensen
Jun 20, 2019·Basic & Clinical Pharmacology & Toxicology·Alexandre StevensDavid Boels
Jan 11, 2014·Journal of Diabetes·Senfeng ZhengYoufei Guan
Mar 5, 2013·Pharmacotherapy·Robert S SvingosJohn J Parker
Sep 25, 2015·Journal of Forensic Sciences·Nick SunderlandCarol K Lee
Mar 12, 2017·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Evan S SchwarzJeffrey Brent
Apr 8, 2016·Wiener klinische Wochenschrift·Heidemarie AbrahamianHermann Toplak
Apr 14, 2019·Wiener klinische Wochenschrift·Heidemarie AbrahamianHermann Toplak

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