Antidiabetic potential of dietary polyphenols: A mechanistic review.

Food Research International
David de Paulo FariasGlaucia Maria Pastore

Abstract

Diabetes is a metabolic disorder that has caused enormous harm to the public health worldwide. In this study, we evaluated the potential of phenolic compounds on diabetes management, addressing their mechanisms of action, in addition to discussing the digestion, absorption, metabolism, bioavailability, and toxic effects of these compounds. The intake of phenolic compounds can play a fundamental role on diabetes management, since they can reduce blood glucose levels, oxidative stress, protein glycation, inhibit the activity of dipeptidyl peptidase - IV and other key enzymes related to carbohydrate metabolism, activate various biochemical pathways to improve pancreatic β-cell functions, increase insulin secretion, and improve insulin resistance. In this way, they can be considered a potential strategy in the development of pharmaceutical approaches that aim to reduce complications resulting from the progression of this metabolic pathology.

References

Apr 13, 2005·Lancet·Michael StumvollTimon W van Haeften
Nov 3, 2010·Journal of Ethnopharmacology·Khang Wei OngBenny Kwong Huat Tan
Aug 23, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gopalsamy Rajiv GandhiMichael Gabriel Paulraj
Jun 4, 2013·Forschende Komplementärmedizin = Research in Complementary Medicine·Saeed KianbakhtFataneh Hashem Dabaghian
Nov 1, 2013·The American Journal of Clinical Nutrition·Michael N CliffordAlan Crozier
Feb 15, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wei ChenSi Ping Lan
May 13, 2014·Archives of Biochemistry and Biophysics·Akira Murakami
Oct 10, 2014·The Journal of Endocrinology·Michael RouseJosephine M Egan
Feb 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seoungwoo ShinDeokhoon Park
Mar 12, 2016·Journal of Agricultural and Food Chemistry·Michelle H Johnson, Elvira Gonzalez de Mejia
Jul 16, 2016·Experimental & Molecular Medicine·Sang-Min Jeon
Sep 21, 2016·Critical Reviews in Food Science and Nutrition·Lucia CrascìAnnamaria Panico
Sep 28, 2017·Food Chemistry·Miren Gómez-JuaristiRaquel Mateos
Mar 28, 2018·Archives of Biochemistry and Biophysics·Fabio CastelloPedro Mena
Sep 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Osasenaga Macdonald Ighodaro
Oct 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Veeranjaneyulu Addepalli, Sachin V Suryavanshi
Mar 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Thiago Félix de Miranda PedrosoVirginia Demarchi Kappel Trichez
Mar 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ahmad GhorbaniReza Shafiee-Nick
Mar 28, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lei ChenHui Cao
May 7, 2019·Current Protein & Peptide Science·Rajeev K SinglaArun Garg
May 22, 2019·Food Research International·Fábio Fernandes de AraújoGlaucia Maria Pastore
Aug 4, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qianzhi DingBaiping Ma
Nov 18, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xue-Qin ZhaoJin-Ao Duan

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