Antidiabetic potentials of ethanolic extract of Aristolochia ringens (Vahl.) roots

Journal of Ethnopharmacology
A O SulymanH F Muritala

Abstract

Oral administration of alcoholic decoctions of Aristolochia ringens is used extensively by Traditional Medicine Practitioners (TMP) of Yoruba heritage in South west, Nigeria for the management of diabetes and its associated complications. To assess the potentials of root ethanolic extract of Aristolochia ringens V. (REAR) in the management of diabetes using chemical induced experimental animal model. Qualitative and quantitative analyses were carried out to elucidate chemical constituents of the REAR extract using phytochemical analyses and gas chromatography-mass spectrometry (GC-MS) technique. Streptozotocin (STZ)-induced diabetic rats were orally administered with 75, 150 and 300mg/kg body weight of the REAR, once a day and the blood glucose (GLU) levels were monitored for 14 days. Mechanisms of GLU lowering effect were investigated by performing oral glucose tolerance test (OGTT) and modulation of diabetes associated biomarkers including hepatic glycogen (GLY), GLU, alpha amylase (αAMY) and glucose-6-phosphate dehydrogenase (GPDH) by the extract. Extraction from A. ringens roots using ethanol/water (70/30) yielded 10.25% w/w REAR extract. Preliminary phytochemical profiling of REAR extract revealed the presence of flavonoid...Continue Reading

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Citations

Nov 14, 2018·Mass Spectrometry Reviews·Sara D'AroncoAnnunziata Lapolla
May 8, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Nasreddine El OmariMalika Barkiyou
Jul 2, 2020·Journal of Experimental Pharmacology·Bamlaku Cherie Melaku, Gedefaw Getnet Amare
Jul 2, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·J B AhmadS Sabiu

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