PMID: 2497930May 1, 1989Paper

Antidiabetic sulfonylureas: localization of binding sites in the brain and effects on the hyperpolarization induced by anoxia in hippocampal slices

Brain Research
C MourreM Lazdunski

Abstract

The distribution of antidiabetic sulfonylurea [( 3H]glibenclamide) binding sites is heterogeneous in rat brain. Pyramidal and extrapyramidal motor system contain the highest densities of sites, particularly in the substantia nigra and in the globus pallidus. Only low levels are present in the hypothalamic nuclei and the main medulla oblongata regions. In hippocampal formation the stratum lucidum and the stratum lacunosum moleculare of CA3 show an important density of glibenclamide binding sites. Electrophysiological studies with hippocampal slices show that glibenclamide blocks hyperpolarization induced by anoxia, suggesting the involvement of adenosine triphosphate-sensitive K+ channel in this early hyperpolarization event.

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Citations

Mar 1, 1991·Pflügers Archiv : European journal of physiology·P JonasW Vogel
May 1, 1995·Pflügers Archiv : European journal of physiology·J Röper, F M Ashcroft
Dec 1, 1992·Pflügers Archiv : European journal of physiology·T Ohno-Shosaku, C Yamamoto
Jan 1, 1989·Pflügers Archiv : European journal of physiology·J R de WeilleM Lazdunski
Aug 1, 1991·Journal of Bioenergetics and Biomembranes·N W DavisP R Stanfield
Jan 1, 1996·Journal of Inherited Metabolic Disease·G K Brown, M V Squier
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·M IkedaJ McCulloch
Jan 1, 1994·Experimental Brain Research·C JiangG G Haddad
Nov 3, 1992·Biochemical Pharmacology·M Gopalakrishnan, D J Triggle
Feb 22, 1991·Brain Research·S ZiniY Ben-Ari
Jun 20, 1989·European Journal of Pharmacology·Y B Ari, M Lazdunski
Jun 24, 1992·European Journal of Pharmacology·M AmalricM Lazdunski
Jun 4, 1993·European Journal of Pharmacology·B Allard, M Lazdunski
Feb 15, 1996·European Journal of Pharmacology·T TanakaM Tanaka
May 23, 1996·European Journal of Pharmacology·G Erdemli, K Krnjević
Dec 1, 1995·Pharmacology, Biochemistry, and Behavior·T TanakaM Tanaka
Jun 1, 1990·Trends in Neurosciences·R J Miller
Dec 15, 1992·Biochimica Et Biophysica Acta·S J Ashcroft, F M Ashcroft
Nov 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·D R Gehlert, D W Robertson
Mar 1, 1995·Progress in Neurobiology·J H Benington, H C Heller
Dec 15, 1989·Neuroscience Letters·K Krnjević, Y Ben-Ari
Aug 31, 1992·Neuroscience Letters·C TrombaA Volterra
Nov 12, 1993·Neuroscience Letters·J M Godfraind, K Krnjević

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