PMID: 6751949Nov 1, 1982

Antidiarrhoeal activity of loperamide: studies of its influence on ion transport across rabbit ileal mucosa in vitro

Gut
S HughesL A Turnberg

Abstract

Loperamide is a well-established antidiarrhoeal agent with effects on gastrointestinal motility. We have now shown that the drug influences ion transport. In isolated rabbit ileal mucosa loperamide caused a dose-related fall in potential difference and short-circuit current and reduced the serosa to mucosa flux of chloride. The electrical effects were inhibited by naloxone (10(-6)M) suggesting that they were mediated by opiate receptors. Loperamide (10(-6)M) inhibited secretion provoked by heat stable and heat labile E. coli toxins and by prostaglandin E2. We conclude that loperamide is able to inhibit secretion mediated by cAMP or cGNP, and that this may be relevant to its antidiarrhoeal properties.

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M FieldP L Smith
Sep 1, 1976·The Journal of Clinical Investigation·P E IsaacsL A Turnberg
Mar 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·E Beubler, F Lembeck
Feb 1, 1977·Prostaglandins·S M Karim, P G Adaikan
Apr 1, 1977·The American Journal of Digestive Diseases·P Kramer
Jun 21, 1975·British Medical Journal·G N Tytgat, K Huibregtse
Jun 1, 1971·The Journal of Clinical Investigation·D V KimbergE Gershon
Apr 5, 1972·Nature: New Biology·D J EvansD G Evans
May 1, 1971·The American Journal of Physiology·M FieldI McColl
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J F KachurM Field
Jul 1, 1980·The Journal of Clinical Investigation·J DobbinsH J Binder
Aug 1, 1981·Gut·B K SandhuJ T Harries

Citations

Mar 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·U M Farack, K Loeschke
Feb 1, 1992·Digestive Diseases and Sciences·G StacherG Stacher-Janotta
Aug 3, 1984·European Journal of Pharmacology·F AppiaC Vaille
Jan 2, 1985·European Journal of Pharmacology·M R DashwoodC S Thompson
Oct 15, 1995·European Journal of Pharmacology·R Callaghan, J R Riordan
Jan 1, 1990·British Journal of Clinical Pharmacology·W P HopmanC B Lamers
Nov 1, 1995·British Journal of Pharmacology·C T Taylor, A W Baird
May 1, 1990·The Journal of Pharmacy and Pharmacology·J HardcastleJ Goldhill
Nov 10, 1984·British Medical Journal·D C Candy
May 16, 2006·Digestive Diseases·Michael J G Farthing
Oct 19, 2010·Gastroenterology Clinics of North America·Alexandra J Kent, Matthew R Banks
Oct 19, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·T B LimaE Leonardecz
Jul 1, 1997·Inflammatory Bowel Diseases·S Urayama, E B Chang
Jan 24, 2019·Breast Cancer Research and Treatment·Hope S RugoLinda Bosserman
Jun 1, 1987·Alimentary Pharmacology & Therapeutics·H Ruppin
Dec 1, 1989·DICP : the Annals of Pharmacotherapy·R F SottileB Mehl
Dec 31, 2019·Gastroenterology Research and Practice·Michel Archange Fokam TagneJean-Louis Essame Oyono

Related Concepts

Bacterial Toxins
Chloride Ion Level
Alkalescens-Dispar Group
Ileum
Structure of Intestinal Gland
Imodium
Resting Potentials
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Piperidines
Prostaglandins E

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