Apr 1, 1988

Antidotal and antineoplastic properties of copper sulfate

Biulleten' eksperimental'noĭ biologii i meditsiny
A B Syrkin, E L Chlenova

Abstract

Copper sulfate in peroral administration to small experimental animals has an inhibitory effect on the growth of transplanted solid tumors and possesses antidote properties in respect to cisplatin. An antitumor effect of the compound was registered at doses ranging from 10 to 120 mg/kg. Antidote properties are manifested clearly when copper sulfate is applied at a single dose 10 mg/kg, 24 hours before cisplatin administration. It has been determined that copper sulfate decreases acute toxicity, nephro- and hemotoxicity of cisplatin, but fails to change its antitumor effect. The experimental data obtained give the ground for the clinical studies of copper sulfate.

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References

  • References1
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Citations

Mentioned in this Paper

Antineoplastic Agents
Neoplasm Transplantation
Copper
Copper Sulfate
Solid Tumour
Brachydactyly
Antidote [EPC]
Cisplatin
NSC-119875
Antidote

About this Paper

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