Antidote control of aptamer therapeutics: the road to a safer class of drug agents

Current Pharmaceutical Biotechnology
Kristin M BompianiBruce A Sullenger

Abstract

Aptamers, or nucleic acid ligands, have gained clinical interest over the past 20 years due to their unique characteristics, which are a combination of the best facets of small molecules and antibodies. The high binding affinity and specificity of aptamers allows for isolation of an artificial ligand for theoretically any therapeutic target of interest. Chemical manipulations of aptamers also allow for fine-tuning of their bioavailability, and antidote control greatly expands their clinical use. Here we review the various methods of antidote control of aptamer therapeutics--matched oligonucleotide antidotes and universal antidotes. We also describe the development, recent progress, and potential future therapeutic applications of these types of aptamer-antidote pairs.

Citations

Jun 18, 2014·Molecular Therapy. Nucleic Acids·Jiehua Zhou, John J Rossi
Feb 18, 2016·Nucleic Acid Therapeutics·Shahid M NimjeeRichard C Becker
Mar 18, 2016·The Protein Journal·Maryam Tabarzad, Marzieh Jafari
Jul 30, 2014·Journal of Chromatography. a·Jonathan AshbyWenwan Zhong
Jul 15, 2016·Journal of Immunology Research·M M SoldevillaF Pastor
May 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina Romero-LópezAlfredo Berzal-Herranz
Jul 18, 2018·Current Opinion in Hematology·Charlene V ChabataRuwan Gunaratne
Oct 21, 2018·Pharmaceuticals·Mario M SoldevillaFernando Pastor
Feb 25, 2021·Chemical Communications : Chem Comm·Yudai TabuchiMasumi Taki

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