Antidotes: benefits and risks

Toxicology Letters
A T Proudfoot

Abstract

The ability of naloxone and flumazenil to reverse serious toxicity due to their respective agonists is well known. Their adverse effects are minor and few but flumazenil administration may unmask seizures in poisoning with combinations of benzodiazepines and tricyclic antidepressants. The desferrioxamine challenge test is frequently falsely negative and should be abandoned. In addition to being cytoprotective, N-acetylcysteine has potent vasodilator and positive inotropic actions which may be partly responsible for its beneficial effect in late-presentation paracetamol overdosage with hepatic damage and failure.

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Citations

Jan 1, 1996·Peptides·G A OlsonA J Kastin
Apr 22, 2006·Pediatric Emergency Care·Joe Brierley
Oct 12, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Anne-Michelle Ruha

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