PMID: 3873268Apr 15, 1985

Antidromic activation of dorsal raphe neurons from neostriatum: physiological characterization and effects of terminal autoreceptor activation

Brain Research
S F SawyerP M Groves

Abstract

Three types of neurons, distinguished on the basis of their spontaneous firing rates and patterns, extracellularly recorded waveforms and responses to neostriatal stimulation, were observed in the dorsal raphe nucleus in urethane-anesthetized rats. Type 1 neurons (presumed to be serotonergic) fired spontaneously from 0.1 to 3 spikes/s in a regular pattern, with initial positive-going bi- or triphasic action potentials. Type 1 cells exhibited long-latency antidromic responses to neostriatal stimulation (mean +/- S.E.M. 24.9 +/- 0.3 ms) that sometimes occurred at discrete multiple latencies, and supernormal periods persisting up to 100 ms following spontaneous spikes. Type 2 cells fired spontaneously in an irregular, somewhat bursty pattern from 0 to 2 spikes/s with initial negative-going biphasic spikes, and were antidromically activated from neostriatal stimulation at shorter latencies than Type 1 cells (21.8 +/- 0.9 ms). Type 3 cells were characterized by initial positive-going biphasic waveforms and displayed a higher discharge rate (5-30 spikes/s) than Type 1 or Type 2 cells. Type 3 cells could not be antidromically activated from neostriatal stimulation. The relatively long conduction time to neostriatum of the Type 1 presu...Continue Reading

References

Mar 12, 2004·Progress in Neurobiology·Izhar Bar-GadHagai Bergman
Jan 1, 1990·Annals of the New York Academy of Sciences·J M Tepper, P M Groves
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ethan S Bromberg-MartinKae Nakamura
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kae NakamuraOkihide Hikosaka
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Jun 27, 2015·Neuropharmacology·Claudia SaghedduMarco Pistis
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Sep 15, 1978·European Journal of Pharmacology·J Davies, P Tongroach
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Related Concepts

Neostriatum
Calcium
Serotonin Measurement
Regulation of Serotonin Secretion
Intravenous Injections
August Rats
Neurons
Serotonin
Action Potentials
Lentiform Nucleus Structure

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