Antidromic burst activity of locus coeruleus neurons during cortical spreading depression

Neuroscience
S ArakawaY Fujii

Abstract

The electrical activity of locus coeruleus neurons was investigated during cortical spreading depression in urethane-anaesthetized rats. Cortical spreading depression was induced by a direct application of 1-3 M KCl solution to the surface of the cerebral cortex. The occurrence of cortical spreading depression was assessed by recording negative d.c. shifts and in some experiments by monitoring the extracellular potassium concentrations. The mean spontaneous firing rate of locus coeruleus neurons was significantly reduced during cortical spreading depression. Approximately 60% of locus coeruleus neurons recorded during cortical spreading depression revealed anomalous burst activity consisting of multiple initial segment spikes as well as full initial segment-somatodendritic spikes with a marked initial segment-somatodendritic break. Each spike of the cortical spreading depression-related burst activity occurred at intervals ranging from 15.0 ms to 90.1 ms (34.9 +/- 0.5 ms). The burst activity appeared unpredictably at variable intervals in a phasic or tonic manner during cortical spreading depression. The cortical spreading depression-related burst activity of locus coeruleus neurons mimicked antidromic spikes induced by train s...Continue Reading

References

Nov 1, 1977·Electroencephalography and Clinical Neurophysiology·M Ueda, J Bures
Jan 1, 1977·Progress in Neurobiology·D G Amaral, H M Sinnamon
Mar 1, 1978·The Journal of Comparative Neurology·J M Cedarbaum, G K Aghajanian
Jan 1, 1978·Neuroscience·R P Kraig, C Nicholson
Jun 1, 1977·The Journal of Physiology·S Nakamura
Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·G G SomjenJ N Young
Nov 1, 1989·Neurologia Medico-chirurgica·K SunamiH Makino
Mar 1, 1988·Journal of Pharmacological Methods·K H ReidA Wauquier
May 24, 1988·Brain Research·M Nedergaard, A J Hansen
Jan 1, 1985·Experimental Brain Research·D Pinault, R Pumain
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Feb 1, 1974·European Journal of Pharmacology·J KorfG K Aghajanian
May 1, 1974·The Journal of Comparative Neurology·V M PickelF E Bloom
May 1, 1984·Brain Research·M M Haglund, P A Schwartzkroin
Jan 1, 1964·Acta Physiologica Scandinavica. Supplementum·C J CLEMEDSON, A JOENSSON
Feb 9, 1965·Zeitschrift für Zellforschung und mikroskopische Anatomie·K FUXE

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Citations

Jun 27, 1998·Current Opinion in Neurology·A A Parsons
Jul 24, 2014·Cephalalgia : an International Journal of Headache·Philip R Holland
May 3, 2003·Nature Reviews. Neuroscience·Daniela Pietrobon, Jörg Striessnig
May 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Hiromu MonaiHajime Hirase
Dec 9, 1998·The American Journal of Physiology·P M SmithA V Ferguson

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