Antidyslipidemic activity of furano-flavonoids isolated from Indigofera tinctoria

Bioorganic & Medicinal Chemistry Letters
Tadigoppula NarenderRamesh Chander

Abstract

Flavonoids appear to play a major role in reducing the risk of cardiovascular diseases by decreasing the blood lipid levels. In continuation of our drug discovery program on antidyslipidemic agents we have isolated three furano-flavones 1-3 and a rare flavonol glycoside 4 from the aerial parts of Indigofera tinctoria. Our results disclose that the treatment with diastereomeric flavonoid mixture 1 and 2 (80:20) significantly decreased the plasma triglycerides (TG) by 60%, total cholesterol (TC) 19%, glycerol (Gly) 13%, and free fatty acid (FFA) 25% accompanied with increase in high density lipoproteins-cholesterol (HDL-C) by 8% and HDL-C/TC ratio 36% in high fat diet (HFD) fed dyslipidemic hamsters at the dose of 50 mg/kg body weight. The flavonoid 3 has exhibited moderate antidyslipidemic activity.

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Oct 26, 2005·Bioorganic & Medicinal Chemistry Letters·Tadigoppula NarenderRamesh Chandra

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Citations

Jul 31, 2013·Journal of Natural Products·Lynette Bueno PérezA Douglas Kinghorn
Sep 27, 2008·Pakistan Journal of Biological Sciences : PJBS·S BakassoO G Nacoulma
Feb 24, 2015·Frontiers in Microbiology·Ana Thereza Bezerra Dos SantosVera Lúcia de Menezes Lima
Feb 1, 2020·Journal of Ethnopharmacology·Elise GeromettaAnne Gauvin-Bialecki
Apr 9, 2021·Rapid Communications in Mass Spectrometry : RCM·Monika Beszterda, Rafał Frański

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