PMID: 6171686Jan 1, 1980Paper

Antidysrhythmic and electrophysiological effects of a new antianginal agent, bepridil

Journal of Cardiovascular Pharmacology
K A Kane, E Winslow

Abstract

The antidysrhythmic effects of a new antianginal agent, bepridil, were compared with those of disopyramide, a known antidysrhythmic drug. Bepridil (20, 50, and 100 mg/kg, i.p.) conferred little protection against aconitine-induced dysrhythmias in mice, whereas similar doses of disopyramide exerted a marked dose-dependent antidysrhythmic effect. Intravenous administration of either bepridil (2 mg/kg) or disopyramide (10 mg/kg) significantly reduced the number of ventricular extrasystoles and completely abolished the occurrence of ventricular fibrillation following coronary artery ligation in the rat. Local anesthetic and electrophysiological effects in vitro of bepridil were also investigated. A marked but slowly developing reduction in action potential height of desheathed frog sciatic nerves was observed at concentrations of 0.01-0.05 mM. In sheep Purkinje fibres, a similar decrease in action potential height, associated with a pronounced reduction in the maximum rate of depolarization of phase zero of the action potential (MRD) was seen with bepridil (0.5-2 X 10(-5) M). Higher concentrations (2-8 X 10(-5) M) were required to reduce MRD of guinea pig ventricular muscle. The antidysrhythmic actions of bepridil may at least in p...Continue Reading

Citations

Dec 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·H HashimotoM Nakashima
Sep 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·F Chollet-DebordP Duchene-Marullaz
Apr 24, 1981·European Journal of Pharmacology·S Mras, N Sperelakis
Apr 23, 1985·European Journal of Pharmacology·J J LynchB R Lucchesi
May 30, 1989·European Journal of Pharmacology·R R BrooksC M Gregory
Sep 1, 1990·Steroids·M MokotoffQ J Liao
Jan 1, 1984·Pharmacology & Therapeutics·E Winslow
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·B Lucas-HeronC Leoty
Nov 1, 1993·General Pharmacology·M P ReillyT Asakura
Aug 1, 1993·Journal of Pharmacological and Toxicological Methods·P H CheungM J Walker
Oct 31, 1996·European Journal of Pharmacology·N SatoK Kikuchi
Feb 6, 1988·Lancet
Jun 5, 2001·Japanese Journal of Pharmacology·Y Watanabe, J Kimura
Mar 1, 1997·Neuropharmacology·A SobolevskyB I Khodorov
Dec 5, 1989·The American Journal of Cardiology·P Jaillon, M Drici
Mar 15, 1985·The American Journal of Cardiology·B N SinghM Schwab
Mar 15, 1989·The American Journal of Cardiology·W J RemmeC J Storm
Sep 1, 1986·The American Journal of Cardiology·J O Parker, B Farrell
Jun 1, 1989·International Journal of Cardiology·H K NielsenR J Pluymers
Jan 1, 1985·American Heart Journal·J SombergS Gottlieb
Jun 1, 1984·The American Journal of Cardiology·A SassineP Puech
Jan 1, 1990·Pacing and Clinical Electrophysiology : PACE·R M CampbellD M Roden
Jun 1, 1981·British Journal of Pharmacology·R J Marshall, A W Muir

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