Antiedematogenic activity and phytochemical composition of preparations from Echinodorus grandiflorus leaves

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Eliana de Faria GarciaFernão Castro Braga

Abstract

The leaves of Echinodorus grandiflorus (Alismataceae) are traditionally used in Brazil to treat inflammatory conditions. The aim of the present study was to evaluate the antidematogenic activity of crude aqueous, dichloromethane and hydroethanolic extracts from E. grandiflorus leaves using the carrageenan-induced paw edema model in mice, along with of fractions enriched in diterpenes, flavonoids and hydroxycinnamoyltartaric acids (HCTA). Significant inhibitions of paw edema were elicited by the 50% and 70% EtOH extracts (1000 mg/kg, p.o.), as well as by the fractions enriched in diterpenes (70-420 mg/kg, p.o.) and flavonoids (7.2-36 mg/kg, p.o.). Isovitexin, isoorientin, trans-aconitic and chicoric acids were identified in all extracts by HPLC analysis. Trans-aconitic acid itself exhibited significant antiedematogenic effect (270 mg/kg, p.o.). The biological activity correlated positively with the contents of flavonoids and diterpenes, but negatively with HCTA concentrations, demonstrating the participation of the two classes of compounds in the antiedematogenic activity of E. grandiflorus.

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Citations

Jan 19, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Thiago Buno Lima PrandoArquimedes Gasparotto Junior
Sep 1, 2015·Journal of Ethnopharmacology·Thiago Buno Lima PrandoArquimedes Gasparotto Junior
Jun 23, 2015·Phytotherapy Research : PTR·Priscilla R V CampanaFernão C Braga
Jul 24, 2014·Anais Da Academia Brasileira De Ciências·Rafaela F LunardiCaroline Dani
Jan 13, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Diego Pinto de OliveiraFernão Castro Braga

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