Antiedematogenic and antioxidant properties of high molecular weight protein sub-fraction of Calotropis procera latex in rat

Journal of Basic and Clinical Pharmacy
Priyanka ChaudharyVijay L Kumar

Abstract

The aim was to evaluate the effect of high molecular weight protein fraction of Calotropis procera latex on edema formation and oxidative stress in carrageenan-induced paw inflammation. A sub-plantar injection of carrageenan was given to induce edema in the hind paw of the rat. The inhibitory effect of high molecular weight protein fraction of C. procera latex was evaluated following intravenous administration (5 and 25 mg/kg body weight) and was compared with that of diclofenac given orally (5 mg/kg). The levels of reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and myeloperoxidase (MPO) were measured in the inflamed paw tissue at the end of the study. The high molecular weight protein fraction obtained from the latex of C. procera produced a dose-dependent inhibition of edema formation that was accompanied by normalization of levels of oxidative stress markers (GSH and TBARS) and MPO, a marker for neutrophils in the paw tissue. The high molecular weight protein fraction of C. procera latex ameliorates acute inflammation in the paw through its antioxidant effect.

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Citations

Jan 21, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Nylane Maria Nunes de AlencarMarcio Viana Ramos
Apr 3, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Márcio V RamosIngrid Samantha T de Figueiredo
May 29, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Danielle Cristina de Oliveira NascimentoJose Vitor Lima-Filho
Feb 23, 2018·Phytotherapy Research : PTR·Mirele S VasconcelosMárcio V Ramos
Nov 11, 2015·BMC Complementary and Alternative Medicine·Naglaa Gamil ShehabFatehia A Bayoumi
Jun 4, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Márcio V RamosGerly Anne C Brito
Jul 13, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Carolina Araújo VianaNylane Maria Nunes Alencar
Apr 10, 2020·Current Medicinal Chemistry·Haitang LiuXuejun Pan
Nov 26, 2020·Memórias do Instituto Oswaldo Cruz·Brandon Ferraz SousaMárcio Viana Ramos
Jun 14, 2021·Research in Veterinary Science·Ana CarolinaSilveira RabeloMaria Angélica Miglino

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Methods Mentioned

BETA
ion-exchange chromatography
ion-exchange
electrophoresis
MDA

Software Mentioned

Statistical Package for the Social Sciences

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