PMID: 2495937DOI: 10.1016/0920-1211(89)90047-8Mar 1, 1989Paper
Antiepileptic and behavioural actions of MK-801 in an animal model of spontaneous absence epilepsy
Epilepsy Research
B W PeetersA M Coenen
Abstract
The effects of MK-801, a non-competitive antagonist at the NMDA receptor, were studied in an animal model of spontaneous absence epilepsy (the WAG/Rij rat strain). MK-801 was found to reduce the number of spike-wave discharges and their mean duration. It also caused certain behavioural abnormalities, such as headweaving [corrected] and agitation. The antiepileptic effects of MK-801 may be due to the involvement of the NMDA receptor in absence epilepsy. An alternative hypothesis is, however, that MK-801 induces an increase in agitation which in turn reduces the epileptic activity.
References
Mar 1, 1988·Neuropharmacology·J M WarterC Marescaux
Jun 1, 1988·Neuropharmacology·J O McNamaraD W Bonhaus
Jul 17, 1986·Nature·C E HerronG L Collingridge
Mar 31, 1987·European Journal of Pharmacology·G MichelettiM Vergnes
Oct 20, 1986·Neuroscience Letters·E L van Luijtelaar, A M Coenen
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E H WongL L Iversen
Jan 1, 1986·European Neurology·J Vieth
Sep 24, 1982·European Journal of Pharmacology·S J Czuczwar, B Meldrum
Jun 1, 1984·Epilepsia·C MarescauxJ M Warter
Nov 1, 1984·Physiology & Behavior·E L van Luijtelaar, A M Coenen
Nov 16, 1982·Neuroscience Letters·M VergnesJ M Warter
May 21, 1982·Science·M J CroucherB S Meldrum
❮ Previous
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Citations
Feb 1, 1995·Annals of Neurology·O C Snead
Jul 18, 1989·European Journal of Pharmacology·A G Chapman, B S Meldrum
Jan 17, 1991·European Journal of Pharmacology·W LöscherM Ganter
Jan 1, 1990·Life Sciences·B W PeetersA M Coenen
Jan 1, 1994·Life Sciences·A CapassoL Sorrentino
Jan 1, 1995·Neuropharmacology·P K Banerjee, O C Snead
Apr 1, 1995·Neuropharmacology·E L van Luijtelaar, A M Coenen
Aug 1, 1990·Trends in Pharmacological Sciences·R DingledineJ O McNamara
Jan 1, 1994·Brain Research Bulletin·B W PeetersA M Coenen
Oct 1, 1992·Epilepsy Research·N AtesA M Coenen
Jul 1, 1992·Epilepsy Research·A M CoenenE L van Luijtelaar
Jan 1, 1993·Epilepsy Research·C E StafstromJ L Thompson
Sep 1, 1996·Epilepsy Research·C KoernerM Vergnes
Nov 17, 2001·European Journal of Pharmacology·R M KamińskiG Van Luijtelaar
Mar 29, 2001·Physiology & Behavior·I A KliouevaS A Chepurnov
Apr 6, 2001·Neurochemistry International·J FilakovszkyG Bagdy
May 29, 1998·Progress in Neurobiology·L DanoberC Marescaux
Mar 19, 1999·Neuroscience Letters·J FilakovszkyG Bagdy
Sep 5, 2002·Neuroscience·S H S LinO Civelli
Mar 20, 2001·Epilepsy Research·R Q HuO C Snead
Feb 18, 1999·Epilepsy Research·B BudziszewskaW Lasoń
Sep 30, 1998·The European Journal of Neuroscience·T SeidenbecherH C Pape
Dec 21, 2002·The European Journal of Neuroscience·Giovanna D'ArcangeloMassimo Avoli
Oct 1, 1991·The European Journal of Neuroscience·Tommy AnderssonKrister Kristensson
Jan 27, 2006·Genes, Brain, and Behavior·M D'AntuonoM Avoli
Jan 1, 1991·Journal of Receptor Research·C M van RijnA M Coenen
Feb 24, 2009·Computers in Biology and Medicine·Elif Derya UbeyliNurbay Ateş
Jan 9, 2007·Neurobiology of Disease·D MerloM Avoli
May 18, 2004·Brain Research·Rita JakusGyorgy Bagdy
Sep 25, 2004·Pharmacology, Biochemistry, and Behavior·I S MidzyanovskayaE L J M van Luijtelaar
Jun 6, 2013·ISRN Neurology·A S Bazyan, G van Luijtelaar
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Emilio RussoGiovambattista De Sarro
Feb 22, 2017·Scientific Reports·Z BaradB Leitch
Jan 16, 1998·Journal of Child Neurology·M A Mikati, G L Holmes
May 24, 2015·Neurosurgical Review·Olaf E M G SchijnsPeter J Koehler
Jan 25, 2007·Reviews on Environmental Health·Jurij J Hostynek
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