Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled cats.

Epilepsia
J A WadaM E Corcoran

Abstract

Acute administration of delta8-tetrahydrocannabinol (delta8-THC) or delta9-THC failed to affect partially developed or fully developed kindled amygdaloid seizures in cats. However, delta9-THC was quite effective in suppressing focal AD in the stimulated amygdala when administered very early in kindling, before the development of any clinical manifestations. This finding suggested that chronic administration of delta9-THC during kindling might block the process of seizure development, which was supported by the observation that three of four cats failed to kindle when treated with the drug. The cat that failed to be protected by delta9-THC was also insensitive to the general electroclinical effects of moderately high doses of delta9-THC. The prophylactic activity of delta9-THC is in contrast to the ineffectiveness of diphenylhydantoin, a drug whose anticonvulsant activity is often compared with that of THC.

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Aug 1, 1973·Experimental Neurology·M E CorcoranJ A Wada
Apr 1, 1973·Experimental Neurology·J A WadaM E Corcoran
Mar 1, 1974·Pharmacology, Biochemistry, and Behavior·J A McCaughranJ A Wada
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Dec 24, 2013·Epilepsia·Vi-Huong Nguyen-MichelVincent Navarro

❮ Previous
Next ❯

Citations

Nov 1, 1980·Neuropharmacology·D A Callaghan, W S Schwark
Jan 1, 1979·Folia Psychiatrica Et Neurologica Japonica·N TsuruJ Idenoue
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
May 7, 2013·Epilepsy Currents·John W Miller
Feb 26, 1979·Life Sciences·M E Corcoran, J A Wada
Aug 14, 2010·Epilepsy & Behavior : E&B·Wolfgang Löscher, Rüdiger Köhling
May 4, 2010·Epilepsy Research·Linda PaulsonRobrecht Raedt
Sep 1, 1980·Journal of Ethnopharmacology·J J Kettenes-van den BoschI Khan
May 24, 2014·Epilepsia·Edward Maa, Paige Figi
Feb 1, 1978·Behavioral Biology·D P Cain, M E Corcoran
Aug 19, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Evan C RosenbergOrrin Devinsky
Apr 1, 1983·Drug and Alcohol Dependence·L E Hollister
Apr 1, 1983·Medicinal Research Reviews·R K Razdan, J F Howes
Aug 1, 1981·Journal of Clinical Pharmacology·E A Carlini, J M Cunha
Apr 11, 2017·Neuropharmacology·Carl R LupicaAlexander F Hoffman
May 9, 2018·Cellular and Molecular Life Sciences : CMLS·Yuki Sugaya, Masanobu Kano
Sep 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Melisa J WallaceRobert J DeLorenzo
Sep 28, 2018·Frontiers in Neurology·Kerstin A KlotzJulia Jacobs
Nov 17, 2020·Frontiers in Neurology·Guilherme Diogo SilvaLécio Figueira Pinto
Jul 13, 2021·Epilepsia·Merrick S FallahW McIntyre Burnham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.