Antiepileptic drug use in nursing home residents: a cross-sectional, regional study

Seizure : the Journal of the British Epilepsy Association
Frauke HuyingKonrad J Werhahn

Abstract

The use of antiepileptic drugs (AED), their primary indication, comorbid conditions, and concomitant medications were collected from 565 nursing homes (NH) residents of six NH located around the city of Mainz, Germany representing 5.05% of all NH residents in the area. Data were collected from the electronic pharmacy files and by reviewing all available medical records. Average age was 82.2 +/- 2.4 years, 85.5% were women. Of 565 NH residents 28 (4.96%) received AED therapy, of which in 17 (63%) AED were prescribed for a seizure-related diagnosis. In 76.5% seizure types were unspecified and a distinction in focal and generalized epilepsy was made in only 23.5% of patients. Three patients never had epileptic seizures and in four residents the reason for AED use was unclear. AEDs most frequently prescribed were carbamazepine (37.1%), valproic acid (25.9%), and phenytoin (14.8%). Five patients received benzodiazepines (18.5%), newer generation AED were used in only four (14.8%) cases. Residents on average took n = 5.6 +/- 3.3 other drugs. Opportunities exist for health care professionals to improve the medical management of nursing facility residents receiving AEDs.

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Citations

Jul 30, 2010·European Journal of Clinical Pharmacology·Mohamad KarouniCecilie Johannessen Landmark
May 3, 2011·European Journal of Clinical Pharmacology·Kristina Johnell, Johan Fastbom
Feb 7, 2015·Pharmacoepidemiology and Drug Safety·Tony AntoniouTara Gomes
Jul 19, 2011·General Hospital Psychiatry·Drieske A HalinkRichard C Oude Voshaar
Mar 26, 2011·Epilepsy Research·Cecilie Johannessen LandmarkSvein I Johannessen
Dec 15, 2015·Epilepsy Research·Carlo Andrea GalimbertiUNKNOWN Elderly Nursing home Epilepsy Assessment—Pavia Study Group
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Jul 19, 2008·Experimental Dermatology·Manuela G NeumanLawrence Cohen
Jul 7, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y H HuangL N Chien
Nov 13, 2012·Seizure : the Journal of the British Epilepsy Association·Doris Patricia HuberEugen Trinka
Nov 21, 2014·Arquivos de neuro-psiquiatria·Telma Rocha de AssisAroldo Bacellar
Mar 14, 2009·The Neurologist·Rosa Ana Saiz DíazJosé Serratosa
Aug 28, 2019·Journal of Clinical Medicine·Syed Shahzad HasanZaheer-Ud-Din Babar
Feb 29, 2020·Drugs & Aging·Blair RajamakiAnna-Maija Tolppanen

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