PMID: 9650679Jul 3, 1998Paper

Antiepileptic drugs and atypical evolution of idiopathic partial epilepsy

Pediatric Neurology
J M PratsP Madoz

Abstract

Six patients with classic benign epilepsy of childhood with centrotemporal spikes, treated with carbamazepine (four patients) or sodium valproate (two patients) evolved atypically because the epileptic disorder, diffusion of the electroencephalographic (EEG) discharges during wakefulness, and continuous spike-and-wave during slow sleep associated with severe neuropsychologic abnormalities worsened. These features appeared after a seizure-free interval varying for 2 weeks to 1 year 6 months after initiating therapy and remitted when the previous anticonvulsant drug was discontinued and either substituted with another drug or the patient was left without any treatment. Once the initial antiepileptic drug was discontinued and after a period roughly proportional to the duration of the clinical-EEG complication, the evolution of the patients' seizures was not unusual for this type of epilepsy, with patients eventually becoming free of both seizures and medication and reaching normal school achievement. The clinical complications cannot be attributed solely to the drugs. It must also be related to the underlying substract (i.e., the specific epileptic syndrome involved) that in some patients becomes susceptible to atypical evolution ...Continue Reading

References

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Citations

Mar 20, 2004·Brain & Development·Roberto Horacio CaraballoNatalio Fejerman
Sep 21, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R MassaM Metz-Lutz
Sep 22, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S GrossoP Balestri
Aug 18, 2009·Epilepsia·Natalio Fejerman
Nov 26, 2009·Pediatric Neurology·Rani A SarkisElaine Wyllie
Apr 10, 2016·Current Treatment Options in Neurology·Mar Carreño, Santiago Fernández
Feb 15, 2003·Journal of Child Neurology·Petia S Dimova, Dimitar S Daskalov
Feb 21, 2003·Journal of Child Neurology·Uri KramerBruria Ben-Zeev
Oct 25, 2000·Epilepsia·E HirschA Arzimanoglou

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