Antiepileptic drugs for preventing seizures in people with brain tumors

The Cochrane Database of Systematic Reviews
I W Tremont-LukatsM R Gilbert

Abstract

Seizures can present at any time before or after diagnosis of a brain tumor. The risk of seizures varies by tumor type and its location in the brain. For a long time we believed that preventing seizures with antiepileptic drugs (seizure prophylaxis) was effective and necessary, but the supporting evidence was little and mixed. Such evidence was the basis for previous reviews to conclude that seizure prophylaxis was ineffective in people with brain tumors. To estimate the effectiveness of seizure prophylaxis in people with brain tumors, and to estimate the adverse event rates in the identified clinical trials. A search strategy that included free-text and MeSH terms in LILACS, EMBASE, PubMed, CENTRAL, and The Cochrane Library (1966 to 2007). Controlled clinical trials with random allocation, blinded or unblinded, and placebo or observation in the control groups. We screened the articles, extracted the data, and rated the validity of each trial to assess the risk of bias. Our primary outcome was the occurrence of a first seizure. The secondary outcome was adverse events. We pooled the aggregate data for each outcome into a random-effects model meta-analysis using the relative risk (RR). For adverse events, we also included the nu...Continue Reading

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Citations

Nov 1, 2012·Neuro-oncology·Roberta RudàRiccardo Soffietti
May 31, 2012·BMC Neurology·Syed Nabeel ZafarMuhammad Shahzad Shamim
Aug 13, 2011·The Cochrane Database of Systematic Reviews·Simon Kerrigan, Robin Grant
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Dec 14, 2019·Journal of Neuro-oncology·Brett E YoungermanJeffrey N Bruce
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Nov 24, 2020·Neurosurgery Clinics of North America·Marco Conti NibaliMarco Riva
May 5, 2021·The Cochrane Database of Systematic Reviews·Maurizio A LeoneEttore Beghi

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