PMID: 11903536Mar 21, 2002Paper

Antiepileptic drugs in migraine prevention

Headache
Ninan T Mathew

Abstract

Migraineurs may continue to experience attacks, despite daily use of one or more agents from a wide range of drugs, including beta-blockers, calcium channel blockers, serotonin antagonists, tricyclic antidepressants, monoamine oxidase inhibitors, and antiepileptic agents. Divalproex sodium is the only antiepileptic drug approved for migraine prevention. Gabapentin, topiramate, and other antiepileptic agents are being evaluated for migraine prevention and treatment. Prospective, double-blind, placebo-controlled clinical trials of divalproex, gabapentin, and topiramate for migraine prevention generally were composed of a prospective baseline period, a dose titration period, and a fixed-dose treatment period. The primary efficacy variable was a reduction in the 28-day frequency of migraine headache. Patients receiving divalproex for 12 weeks at doses up to 1500 mg/day achieved significant decreases in the migraine frequency (P<.05), corresponding to reductions of 30% to 40% compared with baseline. Nearly half of the divalproex-treated patients had a 50% or more reduction from baseline in headache frequencies (P< or =.05). Asthenia, vomiting, somnolence, tremor, and alopecia were common adverse events associated with divalproex. Si...Continue Reading

References

Apr 1, 1992·Cephalalgia : an International Journal of Headache·R Hering, A Kuritzky
Jan 1, 1992·JAMA : the Journal of the American Medical Association·W F StewartM L Reed
Mar 1, 1995·Archives of Neurology·N T MathewR L Deaton
Apr 1, 1997·Cephalalgia : an International Journal of Headache·J Klapper
Oct 26, 1999·Epilepsia·L Magnus
Oct 26, 1999·Epilepsia·T A Glauser
Dec 14, 1999·Cephalalgia : an International Journal of Headache·A Mauskop
Mar 17, 2001·Headache·N T MathewS Tepper

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Citations

Jan 15, 2003·Current Pain and Headache Reports·Jill Corbo
Jun 5, 2013·European Journal of Pharmacology·Alexey Y SokolovSergey S Panteleev
Apr 18, 2003·Medical Hypotheses·A E Eggers
Aug 2, 2002·Epilepsy Research·David J MuzinaJoseph R Calabrese
Jul 2, 2004·Nature Medicine·Michael A Rogawski, Wolfgang Löscher
Apr 22, 2004·The Clinical Journal of Pain·John W Cochran
Jun 15, 2006·Clinical Neuropharmacology·Hortensia Alonso-Navarro, Félix Javier Jiménez-Jiménez
Sep 1, 2006·Neuropsychiatric Disease and Treatment·Ivan Garza, Jerry W Swanson
Feb 14, 2015·Expert Opinion on Drug Safety·László VécseiJános Tajti
Oct 5, 2006·The Journal of Pain : Official Journal of the American Pain Society·Arthur H ElkindUNKNOWN BoNTA-024-026-036 Study Group
Feb 1, 2005·Trends in Pharmacological Sciences·Paolo Calabresi, Letizia Maria Cupini
Mar 1, 2006·Pediatric Neurology·Inga TalvikTiina Talvik
Apr 1, 2003·Expert Opinion on Investigational Drugs·Bianca A Lauria-Horner, Robert B Pohl
May 26, 2006·Expert Opinion on Pharmacotherapy·Sheena Aurora
Oct 2, 2009·The Journal of Headache and Pain·Lars Jacob StovnerKnut Hagen
Oct 12, 2010·Current Opinion in Obstetrics & Gynecology·Stephen A Contag, Cheryl Bushnell
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Erling TronvikGunnar Bovim
Aug 8, 2012·Continuum : Lifelong Learning in Neurology·Paul B Rizzoli
Jul 9, 2003·CNS Drug Reviews·Cecilie U Johannessen, Svein I Johannessen
Jan 10, 2008·Bioorganic & Medicinal Chemistry·Vincent J HuberTsutomu Nakada

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