Antiepileptic drugs management and long-term seizure outcome in post surgical mesial temporal lobe epilepsy with hippocampal sclerosis

Epilepsy Research
José PimentelAntónio G Ferreira

Abstract

Surgery is the treatment of choice for refractory temporal lobe epilepsies, but unexpected seizure recurrences occur and the AEDs management strategy may be an implicated factor. We evaluated the AEDs management's role in the outcome of post surgical epilepsy patients with hippocampal sclerosis (HS). Epileptic patients submitted to amigdalohippocampectomy due to HS in Engel class IA 12 months after surgery were selected. The following variables were studied: age, gender, time of post-surgical follow-up, present Engel class, number of antiepileptic AEDs before surgery and at the time of the interview, AED changes after surgery (stopped, increased, decreased, maintained), timing for AED changes after surgery and seizure recurrences. Sixty-seven consecutive patients were studied (mean time of follow-up of 4.9 ± 2.8 years). Among these, 46.3% were tapering AEDs, 38.8% had not changed and 14.9% had increased AEDs. The global recurrence rate was 32.8%. Recurrence rates for patients tapering and not tapering AEDs were similar (34.2% and 31%, respectively). Fifteen patients tapered AEDs before 2 years and 20 at or 2 years after surgery, with similar recurrence rates (33% and 30%, respectively). All patients who recurred due to AED tape...Continue Reading

References

Aug 4, 2001·The New England Journal of Medicine·S WiebeUNKNOWN Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group
Sep 16, 2003·Epilepsy Research·Heinz-Gregor Wieser, Adrian Häne
Dec 25, 2003·Neurology·S S SpencerUNKNOWN Multicenter Study of Epilepsy Surgery
Nov 3, 2004·Seizure : the Journal of the British Epilepsy Association·Heinz Gregor Wieser, Adrian Häne
Sep 28, 2005·Neurology·S S SpencerUNKNOWN Multicenter Study of Epilepsy Surgery
Jan 19, 2006·Epilepsia·Anne T BergUNKNOWN Multicenter Study of Epilepsy Surgery
Jan 26, 2007·Epilepsy & Behavior : E&B·Anne T BergBarbara G Vickrey
Dec 14, 2007·Epilepsy Research·Michael R SperlingAli A Asadi-Pooya
Dec 18, 2007·Seizure : the Journal of the British Epilepsy Association·Taner TanriverdiAndre Olivier
Jun 24, 2009·Epilepsy & Behavior : E&B·Frank KerlingHermann Stefan

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Citations

Feb 15, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Marta HembMagda Lahorgue Nunes
Mar 13, 2014·Epilepsy Research·Lady D LadinoJosé F Téllez-Zenteno
Dec 17, 2014·Epilepsia·Susanne FauserAndreas Schulze-Bonhage
Jan 24, 2015·Epilepsy & Behavior : E&B·Vibhangini S WasadeMarianna Spanaki-Varelas
May 6, 2015·Epilepsy Research·Michal RyzíMilan Brázdil
Jun 22, 2018·Neurology·Chaturbhuj RathoreKurupath Radhakrishnan
Feb 22, 2014·Current Opinion in Neurology·Kees P J Braun, Dieter Schmidt
Jan 8, 2018·Journal of Neurology·Barbara SchmeiserAndreas Schulze-Bonhage
Jun 20, 2019·Frontiers in Neurology·Chunbo Zhang, Patrick Kwan

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