Antiepileptogenic effects of borneol in pentylenetetrazole-induced kindling in mice

Naunyn-Schmiedeberg's Archives of Pharmacology
Rufi TambeSadhana Sathaye

Abstract

Borneol, a bicyclic monoterpene, can easily cross the blood brain barrier and was found to possess gamma amino butyric acid (GABA) modulatory effect. The present study was aimed at investigating the antiepileptogenic effect of borneol in the pentylenetetrazole (PTZ)-induced kindling besides its ability to suppress oxidative stress and neuroinflammatory marker, glial fibrillary acidic protein (GFAP). Repeated administration of a subconvulsive dose of PTZ (35 mg/kg, i.p.) on every alternate day for 4 weeks produced kindling in mice. Borneol (5, 10, and 25 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.) were given as a pretreatment prior to each PTZ injection during the progression of kindling. Oxidative stress parameters such as superoxide dismutase (SOD), reduced glutathione (GSH), catalase (CAT), and lipid peroxidation (LPO) were assessed at the end of the study. Neuronal damage was assessed by hematoxylin and eosin staining technique. GFAP was also evaluated in the hippocampus region of the brain by using immunohistochemistry. Borneol significantly suppressed the process of epileptogenesis in PTZ-kindled mice. The biochemical alterations induced by PTZ kindling were ameliorated in borneol-treated animals which was indicated by decre...Continue Reading

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Citations

May 9, 2018·The American Journal of Chinese Medicine·Zefeng ZhaoXiaohui Zheng
Dec 11, 2019·Biomolecules·Diogo Vilar da FonsêcaDamião Pergentino de Sousa
Sep 21, 2018·Frontiers in Pharmacology·Suraj MukeSadhana Sathaye
Dec 9, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Sehkar OktayAysen Yarat
Dec 15, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Lícia T S PinaMairim R Serafini
Dec 29, 2020·Epilepsy & Behavior : E&B·Priya MishraSatyendra Kumar Rajput
Feb 21, 2021·Cell Death & Disease·Moran GuoChunyan Li
Oct 16, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shareen Singh, Thakur Gurjeet Singh
Sep 8, 2021·Basic & Clinical Pharmacology & Toxicology·Nian ChenJian Wang

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