Abstract
Borneol, a bicyclic monoterpene, can easily cross the blood brain barrier and was found to possess gamma amino butyric acid (GABA) modulatory effect. The present study was aimed at investigating the antiepileptogenic effect of borneol in the pentylenetetrazole (PTZ)-induced kindling besides its ability to suppress oxidative stress and neuroinflammatory marker, glial fibrillary acidic protein (GFAP). Repeated administration of a subconvulsive dose of PTZ (35 mg/kg, i.p.) on every alternate day for 4 weeks produced kindling in mice. Borneol (5, 10, and 25 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.) were given as a pretreatment prior to each PTZ injection during the progression of kindling. Oxidative stress parameters such as superoxide dismutase (SOD), reduced glutathione (GSH), catalase (CAT), and lipid peroxidation (LPO) were assessed at the end of the study. Neuronal damage was assessed by hematoxylin and eosin staining technique. GFAP was also evaluated in the hippocampus region of the brain by using immunohistochemistry. Borneol significantly suppressed the process of epileptogenesis in PTZ-kindled mice. The biochemical alterations induced by PTZ kindling were ameliorated in borneol-treated animals which was indicated by decre...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Sep 10, 1990·Brain Research·J E Cavazos, T P Sutula
Dec 1, 1988·Analytical Biochemistry·I K SmithC A Thorne
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Oct 24, 1968·Analytical Biochemistry·J Sedlak, R H Lindsay
Dec 1, 1996·Epilepsy Research·M Khurgel, G O Ivy
Apr 8, 1998·Seizure : the Journal of the British Epilepsy Association·W PohleA Willenberg
Nov 27, 1999·Brain Research·C RaucaH Jantze
Jun 1, 2000·Neuroscience·M V FrantsevaM W Burnham
Aug 10, 2000·European Journal of Biochemistry·R DringenJ Hirrlinger
Feb 22, 2001·Free Radical Biology & Medicine·K IshigeY Sagara
Nov 10, 2001·Pharmacology, Biochemistry, and Behavior·H Franke, H Kittner
Aug 2, 2002·Epilepsy Research·Dieter Schmidt
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Y K GuptaA K Srivastava
Mar 15, 2005·Biochemical Pharmacology·Renee E GrangerGraham A R Johnston
May 26, 2005·Neuropharmacology·Atilla IlhanMustafa Iraz
Nov 18, 2005·Neurochemistry International·Hannah SlevenHannah R Cock
Feb 28, 2008·Journal of Neural Transmission·M SakumaT Araki
Feb 25, 2009·Journal of Neural Transmission·S MatsudaTsutomu Araki
Mar 17, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E HorváthováL Wsólová
Jan 9, 2010·Nature Protocols·Christine J Weydert, Joseph J Cullen
Dec 21, 2010·Neuroscience·R LiuG-H Du
Feb 15, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Seema JainKrishna Kishore Sharma
Mar 24, 2011·Epilepsia·Wolfgang Löscher, Dieter Schmidt
Jun 5, 2012·Journal of Agricultural and Food Chemistry·Xican Li
Jun 30, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mohammad Amin SherafatFereshteh Motamedi
Jan 22, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rita de Cássia da Silveira e SáDamião Pergentino de Sousa
May 28, 2013·TheScientificWorldJournal·Jackson Roberto Guedes da Silva AlmeidaLucindo José Quintans
Jan 28, 2015·Journal of Epilepsy Research·Lekha SahaAmitava Chakrabarti
Citations
May 9, 2018·The American Journal of Chinese Medicine·Zefeng ZhaoXiaohui Zheng
Aug 24, 2017·Journal of Separation Science·Yunfei SongBoyang Yu
Jul 11, 2019·Drug Delivery·Shengnan TangPeng Xue
Jun 21, 2020·Basic & Clinical Pharmacology & Toxicology·Marwa A Ahmed, Esam O Kamel
Aug 25, 2019·Science China. Life Sciences·Junchi ZhangJingshan Shen
Mar 14, 2019·Oxidative Medicine and Cellular Longevity·Zi-Xian ChenGuo-Qing Zheng
Dec 11, 2019·Biomolecules·Diogo Vilar da FonsêcaDamião Pergentino de Sousa
Sep 10, 2020·International Journal of Nanomedicine·Yulu ZhangNan Li
Sep 21, 2018·Frontiers in Pharmacology·Suraj MukeSadhana Sathaye
Dec 9, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Sehkar OktayAysen Yarat
Dec 15, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Lícia T S PinaMairim R Serafini
Dec 29, 2020·Epilepsy & Behavior : E&B·Priya MishraSatyendra Kumar Rajput
Feb 21, 2021·Cell Death & Disease·Moran GuoChunyan Li
Mar 23, 2021·Frontiers in Pharmacology·Li-Ying HeChun-Jie Wu
Apr 28, 2021·Neurology India·Neslihan Pinar
Jun 19, 2021·Journal of Ethnopharmacology·Antoine Kavaye KandedaElisabeth Ngo Bum
Aug 7, 2021·Saudi Journal of Biological Sciences·Kaina WangXin Feng
Aug 25, 2021·Metabolic Brain Disease·Tanveer SinghRajesh Kumar Goel
Oct 16, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shareen Singh, Thakur Gurjeet Singh
Sep 8, 2021·Basic & Clinical Pharmacology & Toxicology·Nian ChenJian Wang
Nov 4, 2020·Journal of Ethnopharmacology·Priya MishraJitendra Kumar Sinha