Antiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary

Pharmacological Reports : PR
Antonio LeoRita Citraro

Abstract

WAG/Rij rats represent a validated genetic animal model of epileptogenesis, absence epilepsy and depressive-like comorbidity. Some treatments (e.g. ethosuximide), using specific protocols, prevent the development of spontaneous absence seizures. Accordingly, ethosuximide increases remission occurrence in children with childhood absence epilepsy in comparison to valproic acid. Considering that in this animal model, antiepileptogenic effects are, in some cases, not retained over time, we studied whether the antiepileptogenic effects of both ethosuximide and levetiracetam (which also possesses antiepileptogenic effects in this and other animal epilepsy models) would be retained 5 months after drug suspension. WAG/Rij rats of ˜1 month of age were treated long-term with one of the two drugs at a dose of ˜80 mg/kg/day for 17 consecutive weeks; 1 and 5 months after drug suspension, the development of absence seizures as well as depressive-like behaviour were assessed by EEG recordings and the forced swimming test (FST). In agreement with a previous report, both drugs continued to show antiepileptogenic effects 1 month after their discontinuation. Furthermore, ethosuximide improved depressive-like behaviour, whereas in contrast, leveti...Continue Reading

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Citations

May 1, 2020·Frontiers in Pharmacology·Gilles van Luijtelaar, Gerard van Oijen
Jul 19, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Antonio LeoRita Citraro

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