PMID: 7336465Dec 1, 1981Paper

Antiestrogenic and antifertility actions of Anordrin (2 alpha, 17 alpha-diethynyl-A-nor-5 alpha-androstane-2 beta, 17 beta-diol 2,17-dipropionate)

Steroids
R R MehtaR T Chatterton

Abstract

Anordrin, administered in a single s.c. dose of 62.5 micrograms in sesame oil, stimulated sustained uterine growth (wet weight) when measured at 24 and 72 hr, but total soluble protein and total DNA per uterus was not increased. By comparison, 3 micrograms of estradiol-17 beta under the same conditions significantly increased all three parameters of uterine growth. Both of the above steroid treatments significantly increased nuclear estrogen receptor content of the uterus, but only the estradiol-17 beta treatment resulted in significantly elevated cytosol receptor content per uterus. Anordrin binds to the 8S estrogen receptor with an affinity of about 2 x 10(5) M-1 as determined by competition with [3H]estradiol-17 beta. The abortifacient activity of Anordrin when given orally (8 mg/kg b.w.) to mice on the 7th day of pregnancy was almost completely blocked by simultaneous oral administration of estradiol-17 beta (0.8 mg/kg b.w.). It is concluded that the actions of Anordrin on the uterus can be attributed to its antiestrogenic activities.

References

Jan 1, 1979·Steroids·P CrabbéD Castracane
May 1, 1972·Fertility and Sterility·J Basu
Aug 1, 1971·Journal of Reproduction and Fertility·A Scublinsky, H H Wotiz
Aug 1, 1971·Journal of Reproduction and Fertility·H H Wotiz, A Scublinsky
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Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·U K BANIK, G PINCUS

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Citations

Mar 11, 1991·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·D E LynnA C Wentz
Mar 11, 1991·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·R R Mehta, R T Chatterton
Jun 1, 1994·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·Y C Lu, R T Chatterton
Sep 1, 1993·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·Y C Lu, R T Chatterton
Jul 25, 2000·Contraception·R Kaplan-KraicerR Shalgi
Mar 1, 1993·Contraception·M L ForcelledoH B Croxatto
Sep 1, 1985·Contraception·C Q LiuM Z Dai
May 24, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jinfang JiangDafang Zhong

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