Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy

Advanced Materials
Zhongmin TangWenbo Bu

Abstract

Several decades of research have identified the specific tumor microenvironment (TME) to develop promising nanotheranostics, such as pH-sensitive imaging, acidity-sensitive starving therapy, and hydrogen peroxide-activated chemotherapy, etc. Herein, a novel TME-mediated nanoplatform employing antiferromagnetic pyrite nanocubes is presented, exploiting the intratumoral, overproduced peroxide for self-enhanced magnetic resonance imaging (MRI) and photothermal therapy (PTT)/chemodynamic therapy (CDT). Through the activation of excessive peroxide in the tumor microenvironment, pyrite can lead to in situ surface oxidation and generate hydroxyl radicals to kill tumor cells (i.e., CDT). The increase of the valence state of surface Fe significantly promotes the performance of MRI accompanied by CDT. Furthermore, the localized heat by photothermal treatment can accelerate the intratumoral Fenton process, enabling a synergetic PTT/CDT. To our best knowledge, this is the first study to use the TME-response valence-variable strategy based on pyrite for developing a synergetic nanotheranostic, which will open up a new dimension for the design of other TME-based anticancer strategies.

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Citations

Jun 26, 2018·Advanced Healthcare Materials·Bowen YangJianlin Shi
Sep 28, 2018·Chemical Society Reviews·Yijing LiuXiaoyuan Chen
Dec 1, 2018·Chemical Communications : Chem Comm·Kangqiang QiuHui Chao
Mar 14, 2019·Nanoscale·Hadi Ranji-BurachalooGreg G Qiao
Jul 23, 2019·Advanced Materials·Bowen YangJianlin Shi
Jan 30, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liang YanMin Wei
Jan 14, 2020·Advanced Materials·Huijing XiangYu Chen
Mar 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xue ZhangShiping Yang
May 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuiling JinWei Jiang
Sep 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingdi SunPiaoping Yang
Aug 28, 2019·Nanoscale·Ziliang DongLiangzhu Feng
May 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hanchun YaoBin Du
Jan 30, 2020·Advanced Science·Haohao YinHuixiong Xu
Jun 15, 2019·Journal of Nanobiotechnology·Bin ZhaoQianjun He
Jun 15, 2019·Advanced Healthcare Materials·Tianliang LiDaxiang Cui
Feb 6, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Weiqi WangHaijun Yu
Jan 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chaoqun YouFei Wang

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