Antifibrinolysis with tranexamic acid in aneurysmal subarachnoid hemorrhage: a consecutive controlled clinical trial

Neurosurgery
H FodstadM Schannong

Abstract

A randomized controlled clinical trial was carried out to study the effect of tranexamic acid (AMCA, Cyklokapron; AB Kabi, Stockholm, Sweden) in the prevention of early rebleeding after the rupture of an intracranial aneurysm. The incidence of vasospasm, hydrocephalus, cerebral ischemic and thromboembolic complications, morbidity, and mortality was also evaluated. The series comprises 59 patients, 30 treated with tranexamic acid and 29 controls. The treatment was stopped if there was rebleeding, operation, or discharge from the hospital. There were 6 recurrent hemorrhages in 6 patients in the tranexamic acid-treated group and 11 recurrences in 7 patients in the control group. Recurrent hemorrhages occurred later in tranexamic acid-treated patients than in controls. Five patients in each group died from rebleeding. Five additional treated patients and 2 controls died from cerebral ischemic dysfunction. The results suggest that tranexamic acid may protect patients with ruptured aneurysms from rebleeding for 1 or 2 weeks, but that it also may produce cerebral ischemic complications.

Citations

Jan 1, 1987·Journal of Neurology·K W Lindsay
Apr 4, 2008·Neurocritical Care·Mark ChwajolE Sander Connolly
Jul 16, 2011·Neurocritical Care·R M StarkeUNKNOWN Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management of Subarachnoid He
Mar 14, 2003·Surgical Neurology·A Celal Iplikcioglu, M Zafer Berkman
Aug 1, 1984·Archives of Disease in Childhood·O J HenseyR W Cooke
Feb 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·P Barlow
Dec 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·Y B RoosA Algra
Sep 14, 2010·Critical Care : the Official Journal of the Critical Care Forum·David Royston
Aug 31, 2011·Journal of Neurosurgical Anesthesiology·Kiran BharathSandeep Mohindra
Jan 1, 1990·Acta neurochirurgica·S A TsementzisC H Meyer
Nov 8, 2011·The Annals of Thoracic Surgery·Dimitri KalavrouziotisFrancois Dagenais
Dec 1, 1985·Surgical Neurology·J I AusmanC S Son
Feb 27, 2014·Asian Cardiovascular & Thoracic Annals·Bakhtiari Rostam EsfandiariMajid Kabiri
Aug 31, 2013·The Cochrane Database of Systematic Reviews·Merih I BaharogluYvo B W E M Roos
Jan 1, 1987·British Journal of Neurosurgery·B LjunggrenT Ryman
Oct 9, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Signe V LauridsenAnne-Mette Hvas
Nov 21, 1981·British Medical Journal·J R Bartlett
Jun 20, 2020·Neurosurgical Review·José Luiz de FariaNícollas Nunes Rabelo
Aug 5, 2021·Surgical Neurology International·Resi PrastikaruniaIrwan Barlian Immadoel Haq

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