Antifibrinolytics for heavy menstrual bleeding

The Cochrane Database of Systematic Reviews
A LethabyI Cooke


Heavy menstrual bleeding (HMB) is an important cause of ill health in women. Medical therapy, with the avoidance of possibly unnecessary surgery, is an attractive treatment option. A wide variety of medications are available to reduce heavy menstrual bleeding but there is considerable variation in practice and uncertainty about the most appropriate therapy. Plasminogen activators are a group of enzymes that cause fibrinolysis (the dissolution of clots). An increase in the levels of plasminogen activators has been found in the endometrium of women with heavy menstrual bleeding compared to those with normal menstrual loss. Plasminogen activator inhibitors (antifibrinolytic agents) have therefore been promoted as a treatment for heavy menstrual bleeding. There has been a reluctance to prescribe tranexamic acid due to possible side effects of the drugs such as an increased risk of thrombogenic disease (deep venous thrombosis). Long term studies in Sweden, however, have shown that the rate of incidence of thrombosis in women treated with tranexamic acid is comparable with the spontaneous frequency of thrombosis in women. To determine the effectiveness of antifibrinolytics in achieving a reduction in heavy menstrual bleeding. All stu...Continue Reading


Oct 1, 1977·British Journal of Obstetrics and Gynaecology·P J HaynesA C Turnbull
Jul 1, 1991·British Journal of Obstetrics and Gynaecology·G ChamberlainL Eve
May 1, 1991·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J M Higham, R W Shaw
Jan 1, 1988·Acta Obstetricia Et Gynecologica Scandinavica·B AnderschG Rybo
Oct 24, 1970·British Medical Journal·S T CallenderE Cope
Oct 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·S K ColeA M Thomson
Jan 1, 1965·Acta Obstetricia Et Gynecologica Scandinavica·L Nilsson, G Rybo
Jan 1, 1966·Acta Obstetricia Et Gynecologica Scandinavica·L HallbergG Rybo
Aug 1, 1984·American Journal of Obstetrics and Gynecology·I S FraserR Markham
Apr 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·D GathA Day
Jan 1, 1995·International Journal of Technology Assessment in Health Care·A CoulterM C Rees
May 1, 1995·British Journal of Obstetrics and Gynaecology·J T PrestonS K Smith
Aug 1, 1995·British Journal of Obstetrics and Gynaecology·A ClarkeK Howle

❮ Previous
Next ❯


Nov 3, 2012·Archives of Gynecology and Obstetrics·Hatem Abu Hashim
Jan 22, 2011·Obstetrics and Gynecology·Shannon K Laughlin, Elizabeth A Stewart
Jun 22, 2013·European Journal of Medical Research·David C HoaglinRisha Gidwani
Sep 8, 2012·International Journal of Women's Health·Henri Leminen, Ritva Hurskainen
Dec 21, 2013·The Permanente Journal·Malcolm G Munro, UNKNOWN Southern California Permanente Medical Group’s Abnormal Uterine Bleeding Working Group
Jul 19, 2017·Journal of Gynecology Obstetrics and Human Reproduction·Y Levy-ZaubermanH Fernandez
Apr 16, 2018·The Cochrane Database of Systematic Reviews·Alison C Bryant-SmithMartha Hickey
Nov 3, 2017·Blood·Kochawan BoonyawatShannon M Bates
Nov 3, 2016·The Cochrane Database of Systematic Reviews·Gabriela PrutskyRoberto Accinelli
Nov 15, 2016·The Cochrane Database of Systematic Reviews·Sujoy Ray, Amita Ray
Jun 17, 2015·The Cochrane Database of Systematic Reviews·Natalia NovikovaCatherine Cluver
May 25, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Kari Hilde Juvkam, Hilde Beate Gudim
Dec 1, 2011·Hämostaseologie·S Halimeh
Jan 11, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Becky Naoulou, Ming C Tsai
Jan 29, 2016·The Cochrane Database of Systematic Reviews·Jane MarjoribanksCindy Farquhar
Apr 23, 2017·Wiener klinische Wochenschrift·Ingrid PabingerWolfgang Toller
Sep 22, 2016·Journal of Obstetrics and Gynaecology of India·Priyankur RoyAnumita Chatterjee
Sep 22, 2016·Journal of Obstetrics and Gynaecology of India·Priyankur RoyBivas Biswas
Mar 4, 2021·Reproductive Biology and Endocrinology : RB&E·Yingxian JiaJianhong Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.