Antifibrinolytics in women with menorrhagia

Thrombosis Research
Claire S Philipp

Abstract

Heavy menstrual bleeding is associated with increased local fibrinolysis. Antifibrinolytic agents have been used in women with menorrhagia with and without bleeding disorders, and have been demonstrated to decrease menstrual blood flow approximately 50% and improve quality of life. Most studies have been done with the antifibrinolytic agent tranexamic acid, a synthetic lysine derivative. Studies have been performed comparing tranexamic acid with placebo, non-steroidal anti-inflammatory agents, and progesterone in women with menorrhagia and have predominantly demonstrated a greater reduction in menstrual blood flow with tranexamic acid. In women with menorrhagia and an underlying bleeding disorder, tranexamic acid was compared to intranasal desmopressin and also demonstrated a greater reduction in menstrual blood flow. In aggregate the studies demonstrate that antifibrinolytic agents are effective medical management for women with menorrhagia with or without bleeding disorders, reducing menstrual blood flow and improving quality of life.

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Citations

Jul 11, 2014·Briefings in Functional Genomics·Konstantinos HatzikotoulasEleftheria Zeggini
Apr 19, 2013·Archives of Gynecology and Obstetrics·Azita GoshtasebiSamira Behboudi Gandevani
May 1, 2012·Journal of Thrombosis and Haemostasis : JTH·Y XueK Olsson
May 19, 2012·Journal of Midwifery & Women's Health·Anne Z Cockerham
Mar 25, 2014·Medicinal Research Reviews·Rami A Al-Horani, Umesh R Desai
May 31, 2015·Journal of Pediatric and Adolescent Gynecology·Lakshmi V SrivathsDonald Mahoney
Dec 3, 2014·Journal of Ethnopharmacology·Betzabeth Pereira, Josmary Brazón
Dec 7, 2018·Pediatrics in Review·Rudi-Ann GrahamFernando F Corrales-Medina
Jan 9, 2013·Journal of Medicinal Chemistry·Sebastian M SaupeTorsten Steinmetzer

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