Antifibrotic Agent Pirfenidone Protects against Development of Radiation-Induced Pulmonary Fibrosis in a Murine Model

Radiation Research
Wan QinXianglin Yuan

Abstract

Radiation-induced complications of the respiratory system are a common side effect of thoracic radiotherapy with no viable treatment option. Here, we investigated the potential therapeutic effect of the orphan drug pirfenidone for treating radiation-induced pulmonary fibrosis. C57BL/6 mice received a single fraction of 16 Gy to the thorax and were subsequently treated with 300 mg/kg/day pirfenidone for four weeks. Survival and body weight of the mice were quantified. Micro-CT in vivo lung imaging was performed to dynamically observe the developmental process of pulmonary fibrosis. The lungs were excised at the end of the experiment and evaluated for histological changes. Compared to the irradiated mice that received no pirfenidone, mice treated with pirfenidone after irradiation had an extended median survival time (>140 days vs. 73 days, P < 0.01). The accumulation of collagen and fibrosis in lung tissues after irradiation was decreased with pirfenidone treatment. Pirfenidone also reduced the expression of TGF-β1 and phosphorylation of Smad3 in lung tissues. The dose level of Pirfenidone used in this study attenuated pulmonary fibrosis and prolonged the life span of irradiated mice. It may offer a promising approach to treat o...Continue Reading

References

Apr 1, 1988·Journal of Clinical Pathology·T AshcroftV Timbrell
Apr 4, 1998·American Journal of Respiratory Cell and Molecular Biology·G GurujeyalakshmiS N Giri
Aug 27, 1998·International Journal of Radiation Oncology, Biology, Physics·M S AnscherR L Jirtle
Jun 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M I KoukourakisV Georgoulias
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M BrizelR Sauer
Jul 2, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeffrey W CardThomas E Massey
Aug 19, 2003·Journal of Korean Medical Science·Ho-Sun ParkYong-Hoon Park
Apr 28, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alena Novakova-JiresovaHarry J M Groen
Mar 23, 2005·The Journal of Experimental Medicine·Amir AbdollahiPeter E Huber
Mar 21, 2006·Current Opinion in Anaesthesiology·Johann MotschBernd W Böttiger
Jun 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Mitchell S AnscherZeljko Vujaskovic
Mar 31, 2007·Seminars in Radiation Oncology·Michael T MilanoPaul Okunieff
Apr 16, 2008·International Journal of Radiation Oncology, Biology, Physics·Mitchell S AnscherZeljko Vujaskovic
May 13, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Andrea E ParaRichard P Hill
Sep 3, 2010·Fibrogenesis & Tissue Repair·José Macías-BarragánJuan Armendáriz-Borunda
May 17, 2011·Lancet·Paul W NobleUNKNOWN CAPACITY Study Group
Jun 17, 2011·International Journal of Radiation Biology·Javed MahmoodRichard P Hill
Nov 15, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gilda G HillmanAndre A Konski
May 2, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul FlechsigPeter E Huber
Dec 4, 2013·Fibrogenesis & Tissue Repair·Louise WalkinPeter J Margetts
Jan 10, 2014·Current Eye Research·Kihwang LeeHongseok Yang
Mar 13, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Enrico ConteCarlo Vancheri
May 20, 2014·The New England Journal of Medicine·Talmadge E KingUNKNOWN ASCEND Study Group
Oct 1, 2014·Nature Reviews. Clinical Oncology·David Killock
Dec 20, 2014·Future Oncology·Roberta M JohnkeRon R Allison
Jan 22, 2015·Drugs·Esther S Kim, Gillian M Keating
Mar 17, 2015·Seminars in Radiation Oncology·Feng-Ming Spring Kong, Shulian Wang
Apr 10, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Prashanth GiridharPramod Kumar Julka
Oct 22, 2015·Radiation Research·Shanmin YangLurong Zhang
Nov 14, 2015·Annual Review of Medicine·Anna S Selvaggio, Paul W Noble
Mar 17, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rasmi Rajan Radha, Guruvayoorappan Chandrasekharan
Apr 5, 2017·Journal of the National Cancer Institute·Sebastian BickelhauptPeter E Huber
Apr 25, 2017·Radiation Research·Jian WangZhenyu Lin
Sep 4, 2017·Seminars in Radiation Oncology·Charles B Simone
Sep 16, 2017·Scientific Reports·Alexandra PaunChristina K Haston

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Citations

Jan 23, 2020·American Journal of Respiratory Cell and Molecular Biology·Saleela M RuwanpuraPhilip G Bardin
Mar 19, 2019·Oxidative Medicine and Cellular Longevity·Shashank ShrishrimalRebecca E Oberley-Deegan
Oct 4, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Vincent Cottin
Oct 13, 2020·Frontiers in Oncology·Long LiXianglin Yuan
Oct 17, 2020·Radiation Research·Carmen I RiosAndrea L DiCarlo
Feb 2, 2021·Frontiers in Medicine·Natalia JarzebskaPeter M Spieth
Jul 17, 2020·American Journal of Respiratory and Critical Care Medicine·Steven L BrodyYongjian Liu
Feb 16, 2021·Frontiers in Medicine·Soroush Seifirad, Lance Alquran
Nov 28, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Görkem TürkkanDirk De Ruysscher

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Methods Mentioned

BETA
X-ray
electrophoresis

Clinical Trials Mentioned

NCT02296281

Software Mentioned

SPSS

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