Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis.

World Journal of Gastroenterology : WJG
Sahar K HegazyAkira Yagi

Abstract

To investigate the anti-oxidative and anti-fibrotic effects of aloe vera in patients with liver fibrosis. Aloe vera high molecular weight fractions (AHM) were processed by patented hyper-dry system in combination of freeze-dry technique with microwave and far infrared-ray radiation. Fifteen healthy volunteers as the control group and 40 patients were included. The patients were randomly subdivided into two equal groups: the conventional group was treated with placebo (starch), and AHM group was treated with 0.15 gm/d AHM, both for 12 consecutive weeks. The patients were investigated before and after treatment. Serum activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), hyaluronic acid (HA), transforming growth factor-β (TGF-β) and matrixmetalloproteinase-2 (MMP-2) were determined. The reduced glutathione (GSH) and malondialdehyde (MDA) levels in liver were assayed and the expression of hepatic α-smooth muscle actin (α-SMA) was identified by immunohistochemistry. At the start of the study, the hematoxylin and eosin staining revealed fibro-proliferated bile ductules, thick fibrous septa and dense inflammatory cellular infiltration in the patients before treatment. The use of AHM...Continue Reading

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Citations

Jul 10, 2014·BMC Complementary and Alternative Medicine·Duangporn WerawatganonPrasong Siriviriyakul
Oct 8, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maryam AkaberiSeyed Ahmad Emami
Dec 21, 2016·Photodermatology, Photoimmunology & Photomedicine·Eriko MisawaFukumi Furukawa
Jan 7, 2015·World Journal of Gastroenterology : WJG·Duangporn WerawatganonRungsun Rerknimitr
Aug 7, 2021·Phytotherapy Research : PTR·Saeideh SabbaghzadeganMajid Dadmehr

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