Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis

Biochemical Pharmacology
S N GiriM D Pierschbacher

Abstract

We reported previously that treatment with antibody to transforming growth factor-beta (TGF-beta) caused a marked attenuation of bleomycin (BL)-induced lung fibrosis (LF) in mice. Decorin (DC), a proteoglycan, binds TGF-beta and thereby down-regulates all of its biological activities. In the present study, we evaluated the antifibrotic potential of DC in a three-dose BL-hamster model of lung fibrosis. Hamsters were placed in the following groups: (1) saline (SA) + phosphate-buffered saline (PBS) (SA + PBS); (2) SA + DC; (3) BL + PBS; and (4) BL + DC. Under pentobarbital anesthesia, SA (4 mL/kg) or BL was instilled intratracheally in three consecutive doses (2.5, 2.0, 1.5 units/kg/4 mL) at weekly intervals. DC (1 mg/mL) or PBS was instilled intratracheally in 0.4 mL/hamster on days 3 and 5 following instillation of each dose of SA or BL. In week 4, hamsters received three doses of either DC or PBS every other day. The hamsters were killed at 30 days following the first instillation, and their lungs were appropriately processed. Lung hydroxyproline levels in SA + PBS, SA + DC, BL + PBS, and BL + DC groups were 965, 829, 1854, and 1387 microg/lung, respectively. Prolyl hydroxylase activities were 103, 289, and 193% of SA + PBS con...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Dec 27, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·A BurkhardtJ O Gebbers
Jun 1, 1976·The Journal of Clinical Investigation·J M SeyerA H Kang
Jan 1, 1992·Experimental Lung Research·S H Phan, S L Kunkel
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J ReibmanG Weissmann
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T J BroekelmannJ A McDonald
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsJ H Kehrl
Mar 1, 1986·Journal of Biochemical Toxicology·K M ReiserH R Witschi
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Dec 1, 1989·The American Review of Respiratory Disease·C KuhnJ A McDonald
Aug 3, 1989·The New England Journal of Medicine
Jul 1, 1989·The American Review of Respiratory Disease·G RaghuA S Narayanan
Dec 1, 1985·Journal of Applied Physiology·S E GoldblumM Jay
Jun 1, 1987·The Journal of Surgical Research·D T CromackJ A Norton
Oct 1, 1995·Nature Medicine·W A Border, N A Noble

❮ Previous
Next ❯

Citations

Aug 17, 2000·Springer Seminars in Immunopathology·C FonsecaC M Black
Jul 8, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Khaled NassarSalvatore Grisanti
May 19, 2004·The International Journal of Biochemistry & Cell Biology·Eiko Honda, Hiroshi Munakata
Jun 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·N FukuiK Nakamura
Dec 28, 1999·Microbes and Infection·M Reiss
Jul 5, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yong LiJohnny Huard
Apr 14, 2010·The Journal of Trauma·Anandaroop MukhopadhyayThang T Phan
Jan 6, 2006·Journal of Clinical Pathology·J KöningerH Friess
Jan 24, 2003·Annual Review of Pharmacology and Toxicology·Shri N Giri
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·M KolbJ Gauldie
Apr 3, 2002·The Journal of Clinical Investigation·Min HuangSteven M Dubinett
Apr 12, 2006·Journal of Inflammation·Frank J LichtenbergerClay B Marsh
Aug 10, 2000·Environmental Health Perspectives·J A Lasky, A R Brody
Aug 6, 2014·The International Journal of Biochemistry & Cell Biology·Louise Tzung-Harn HsiehLiliana Schaefer
May 23, 2012·Trends in Immunology·Ming ZengTimothy W Schacker
Dec 28, 2010·Cytokine·Laura ArribillagaEsperanza Feijoó
Jul 31, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·S ZanottiM Mora
Oct 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J de KluijverP J Sterk
Aug 31, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hannu JärveläinenThomas N Wight
Mar 7, 2006·Pulmonary Pharmacology & Therapeutics·Katerina M AntoniouNikolaos M Siafakas
Jul 12, 2005·Experimental and Molecular Pathology·Kazuhiko SuzukiTsuneo Sato
Jan 4, 2007·The American Journal of Pathology·Felix ChuaGeoffrey J Laurent
Jul 31, 2002·Biochemical Pharmacology·Mohammed Ali Al-BayatiShri N Giri
Feb 11, 2014·Biochimica Et Biophysica Acta·Madalina V NastaseLiliana Schaefer
May 31, 2013·Veterinary Ophthalmology·Kevin S DonnellyRajiv R Mohan
Jan 20, 2012·The Biochemical Journal·David A CarrinoArnold I Caplan
Dec 16, 2000·Expert Opinion on Investigational Drugs·F M Wigley, S D Sule
Oct 3, 1999·Experimental Neurology·A LoganM Berry
Sep 20, 2007·The Journal of Medical Investigation : JMI·Harumi FurochiTakeshi Nikawa
Jul 22, 1999·Experimental Cell Research·G Serini, G Gabbiani
May 8, 2014·Experimental Eye Research·D KaramichosJ D Zieske
Jan 20, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jama JahanyarKeith A Youker
Nov 26, 2008·Journal of Vascular and Interventional Radiology : JVIR·Sanjay MisraDebabrata Mukhopadhyay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.