Antifibrotic effects of aldosterone receptor blocker (spironolactone) in patients with chronic kidney disease

Renal Failure
Ibrahim GuneySadik Büyükbaş

Abstract

Proteinuria and transforming growth factor beta (TGF-beta) are parameters that can lead to glomerulosclerosis and tubulointerstitial fibrosis. All components of the renin-angiotensin-aldosterone system (RAAS) activate the TGF-beta. Aldosterone may not be inhibited with angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers (ARBs) due to aldosterone escape. We aimed to evaluate the effect of spironolactone on parameters leading to fibrosis. This prospective study included 30 non-diabetic chronic kidney disease (CKD) patients treated with ACEIs and/or ARBs. The patients were divided into two groups that are similar in terms of demographic parameters. 25 mg of spironolactone was added to group 1 (n = 15) for six months, though it was not administered to group 2 (n = 15). Creatinine (U-Cr), protein (U-Prot), and TGF-beta1 (U- TGF-beta1) were measured in spot urine sample in the beginning of study and six months later. Twenty-four patients completed the study. There were no significant changes in mean blood pressure, glomerular filtration rate, creatinine, albumin, and plasma aldosterone concentrations during the observation period in either group. U-Prot/U-Cr (mg/mg Cr) was reduced from 2.43 +/- 4.85 ...Continue Reading

References

Feb 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E HonkanenC Grönhagen-Riska
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·W B Reeves, T E Andreoli
Sep 22, 2001·The New England Journal of Medicine·A Chrysostomou, G Becker
Nov 13, 2001·Kidney International·G S HillJ Bariéty
Dec 11, 2002·Kidney International·Iris FeriaNorma A Bobadilla
May 16, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hyeong Cheon ParkDae Suk Han
Jan 17, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pierina De MuroGian Mario Cherchi
Feb 27, 2004·Cardiovascular Research·Allan D Struthers, Thomas M MacDonald
Jun 18, 2004·Kidney International·Norman K Hollenberg
Jan 11, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Allan J CollinsUNKNOWN United States Renal Data System
Jun 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stefano BianchiVito M Campese
Dec 7, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joon Ho SongMoon-Jae Kim
Dec 13, 2005·Kidney International. Supplement·Giuseppe RemuzziPiero Ruggenenti
May 9, 2006·American Journal of Nephrology·Sotiris Tsakas, Dimitrios S Goumenos
Oct 31, 2006·The American Journal of Medicine·Murray Epstein

❮ Previous
Next ❯

Citations

Jun 12, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marisa GianiAlberto Edefonti
Mar 12, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Florian LangIoana Alesutan
May 15, 2013·Journal of Pharmaceutical and Biomedical Analysis·Ying-Yong ZhaoXu Bai
Sep 16, 2014·Journal of Renal Care·Eric Wombwell, Andrew Naglich
Sep 19, 2014·Seminars in Dialysis·Nikunjkumar Patel, Susie L Hu
Mar 19, 2015·The New England Journal of Medicine·Don C RockeyJoseph A Hill
Aug 10, 2011·Nature Reviews. Nephrology·Devasmita Choudhury, Moshe Levi
Jan 24, 2019·Current Diabetes Reports·Yuliya LytvynDavid Z Cherney
Mar 9, 2019·Current Pharmaceutical Design·Pantelis A SarafidisAikaterini Papagianni
Jun 10, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hiroyuki KadoyaNaoki Kashihara
Jan 15, 2013·International Journal of Molecular Medicine·Sylwia MałgorzewiczJerzy Jankun
Mar 15, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Ali MomeniMohammad Karami Horestani
Jun 15, 2017·Frontiers in Pharmacology·Greg H Tesch, Morag J Young
Aug 10, 2017·Current Hypertension Reports·Fan ZhangHongqing Zhang
Mar 5, 2020·Journal of Veterinary Pharmacology and Therapeutics·Sarah SpencerJonathan Elliott
Nov 23, 2016·European Journal of Heart Failure·Michael R BristowBarry H Greenberg
May 2, 2014·The Cochrane Database of Systematic Reviews·Davide BolignanoGiovanni F M Strippoli
Oct 28, 2020·The Cochrane Database of Systematic Reviews·Edmund Ym ChungGiovanni Fm Strippoli
Nov 13, 2020·Drug Development Research·Vishal PatelMukul Jain
Oct 8, 2020·Pharmacology & Therapeutics·Cosimo CosimatoThomas A Mavrakanas
Mar 6, 2021·Journal of the American College of Cardiology·Iris E BeldhuisAkshay S Desai
May 21, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Lorenzo Villa-ZapataDaniel C Malone
May 5, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alberto OrtizUNKNOWN European Renal and Cardiovascular Medicine (EURECA-m) working group of the European Renal Association—European Dialysis and

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.