Antiflammin-2, a nonapeptide of lipocortin-1, inhibits leukocyte chemotaxis but not arachidonic acid mobilization

European Journal of Pharmacology
J J Moreno

Abstract

We have studied the effects of antiflammin-2, a fragment corresponding to amino acids 246-254 of lipocortin-1 (HDMNKVLDL), on arachidonate mobilization and metabolism and we also determined the effect of antiflammin-2 on the chemotaxis of phagocytes. Our results demonstrated that the antiflammin-2 was not able to diminish significantly [3H]arachidonic acid mobilization stimulated by 4 beta-phorbol-12-myristate 13-acetate or calcium ionophore A23187 in murine 3T6 fibroblasts or resident peritoneal macrophages. Further, antiflammin-2 had no effect on arachidonate metabolism. In contrast, a glucocorticoid such as dexamethasone reduced significantly [3H]arachidonic acid release and arachidonate metabolism induced in both cells. This study confirms the inhibitory effect of antiflammin on leukocyte migration and suggests that it acts partly through the inhibition of leukocyte binding to endothelial cells.

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Citations

Jul 20, 2002·Biochemical and Biophysical Research Communications·Bhabadeb ChowdhuryAnil B Mukherjee
Feb 15, 2003·European Journal of Pharmacology·Rebecca H RitchieGregory J Dusting
Jan 10, 2006·International Immunopharmacology·Juan José Moreno
Mar 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vincenzo BrancaleoneMauro Perretti
Mar 4, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C ZoukiJ G Filep
Feb 24, 2001·Annals of the New York Academy of Sciences·C C ChanD F Shen
Feb 24, 2001·Annals of the New York Academy of Sciences·J J Moreno
Feb 24, 2001·Annals of the New York Academy of Sciences·L Miele

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